ArticleArchivum immunologiae et therapiae experimentalis
Evaluation of selected parameters of the antioxidative system in patients with type 2 diabetes in different periods of metabolic compensation.
Article in Archivum immunologiae et therapiae experimentalis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Carvedilol modifies antioxidant status of patients with stable angina.Cellular & molecular biology letters · 2008Trial
- Alterations in the high density lipoprotein phenotype and HDL-associated enzymes in subjects with metabolic syndrome.Lipids · 2009Article
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Authors and funding
7 authors.
Funding
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Abstract
introductionThe aim of the study was to evaluate some selected parameters of the antioxidative system in patients with type 2 diabetes. MATERIALS AND
methodsEighty-one type 2 diabetes patients took part in the study (39 patients with metabolically balanced and 42 with metabolically unbalanced diabetes). The control group consisted of 30 healthy people. The total antioxidant capacity of plasma was measured fluorometrically using phycoerythrin. To calculate the low-molecular-weight antioxidant concentration in the plasma samples, the duration of Trolox activity as a function of its concentration in the sample was measured. The activity of antioxidative enzymes in red blood cells was determined using the Misra and Fridovich method and Beers and Sizer method.
resultsThe total plasma antioxidant capacity and the low-molecular-weight antioxidant concentration in the group of patients with metabolically compensated type 2 diabetes were statistically significantly higher than in the group of patients with metabolically uncontrolled diabetes. The activity of antioxidative enzymes was found to be higher in the group of type 2 diabetes patients at the stage of metabolic balance.
conclusionsThe obtained results confirm the thesis of glucose toxicity and intensification of oxidative stress in patients with diabetes.
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