ArticleThe Plant cell2008
Functional and physiological characterization of Arabidopsis INOSITOL TRANSPORTER1, a novel tonoplast-localized transporter for myo-inositol.
Article in The Plant cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 93 citations in OpenAlex.
- Article
- Towards a Holistic View of the Orchestration Between Sugar Transporters in Cereal Crops.Plants (Basel, Switzerland) · 2026Article
- The Vacuolar Inositol Transporter BvINT1;1 Contributes to Raffinose Biosynthesis and Reactive Oxygen Species Scavenging During Cold Stress in Sugar Beet.Plant, cell & environment · 2025Article
- Major Facilitator Superfamily transporters balance sugar metabolism in peach.Plant physiology · 2025Article
- Symplasmic phloem loading and subcellular transport in storage roots are key factors for carbon allocation in cassava.Plant physiology · 2024Article
- The role of sugar transporters in the battle for carbon between plants and pathogens.Plant biotechnology journal · 2024Review
- The Phytophthora parasitica effector AVH195 interacts with ATG8, attenuates host autophagy, and promotes biotrophic infection.BMC biology · 2024Article
- A genome-wide association study of freezing tolerance in red clover (Frontiers in plant science · 2023Article
- How pollen tubes fight for food: the impact of sucrose carriers and invertases ofFrontiers in plant science · 2023Article
- Physiological Importance of Molybdate Transporter Family 1 in Feeding the Molybdenum Cofactor Biosynthesis Pathway inMolecules (Basel, Switzerland) · 2022Article
- Overexpression of Melon Tonoplast Sugar Transporter CmTST1 Improved Root Growth under High Sugar Content.International journal of molecular sciences · 2020Article
- Genome-wide identification, expression, and association analysis of the monosaccharide transporter (MST) gene family in peanut (3 Biotech · 2020Article
- Plant Membrane Transport Research in the Post-genomic Era.Plant communications · 2020Review
- The sugar transporter system of strawberry: genome-wide identification and expression correlation with fruit soluble sugar-related traits in aHorticulture research · 2020Article
- Identification of source-sink tissues in the leaf of Chinese cabbage (Brassica rapa ssp. pekinensis) by carbohydrate content and transcriptomic analysis.Genes & genomics · 2020Article
- Article
- Genome-wide identification of MST, SUT and SWEET family sugar transporters in root parasitic angiosperms and analysis of their expression during host parasitism.BMC plant biology · 2019Article
- Article
- Transcriptome Analysis of Intrusively Growing Flax Fibers Isolated by Laser Microdissection.Scientific reports · 2018Article
- Glucose Uptake via STP Transporters Inhibits in Vitro Pollen Tube Growth in a HEXOKINASE1-Dependent Manner inThe Plant cell · 2018Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arabidopsis thaliana INOSITOL TRANSPORTER1 (INT1) is a member of a small gene family with only three more genes (INT2 to INT4). INT2 and INT4 were shown to encode plasma membrane-localized transporters for different inositol epimers, and INT3 was characterized as a pseudogene. Here, we present the functional and physiological characterization of the INT1 protein, analyses of the tissue-specific expression of the INT1 gene, and analyses of phenotypic differences observed between wild-type plants and mutant lines carrying the int1.1 and int1.2 alleles. INT1 is a ubiquitously expressed gene, and Arabidopsis lines with T-DNA insertions in INT1 showed increased intracellular myo-inositol concentrations and reduced root growth. In Arabidopsis, tobacco (Nicotiana tabacum), and Saccharomyces cerevisiae, fusions of the green fluorescent protein to the C terminus of INT1 were targeted to the tonoplast membranes. Finally, patch-clamp analyses were performed on vacuoles from wild-type plants and from both int1 mutant lines to study the transport properties of INT1 at the tonoplast. In summary, the presented molecular, physiological, and functional studies demonstrate that INT1 is a tonoplast-localized H(+)/inositol symporter that mediates the efflux of inositol that is generated during the degradation of inositol-containing compounds in the vacuolar lumen.
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