Evidence map›Paper›PMID 18469239›Full record

Trial reportThe American journal of clinical nutrition2008

Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals.

Kimber L Stanhope, Steven C Griffen, Brandi R Bair, Michael M Swarbrick, Nancy L Keim, Peter J Havel

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 4 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 4 syntheses or guidelines pooled it, 227 citations in OpenAlex.

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  16. A dual sugar challenge test for lipogenic sensitivity to dietary fructose.The Journal of clinical endocrinology and metabolism · 2011
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kimber L StanhopeDepartment of Molecular Biosciences, School of Veterinary Medicine, Davis, CA 95616-8669, USA.
Steven C Griffen
Brandi R Bair
Michael M Swarbrick
Nancy L Keim
Peter J Havel
University of California, Davis · USWestern Human Nutrition Research Center · US

Funding

UC DAVIS CLINICAL AND TRANSLATIONAL SCIENCE CENTER: BPCAUL1RR024146 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2006 to 2011
$27.0M
Effects of 2wk fructose & HFCS consumption on lipid dysregulation & insulin resisR01HL091333 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAVEL, PETER J · 2008 to 2012
$2.0M
Dietary Fructose: Hormones &TG/Lipoprotein MetabolismR01HL075675 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI HAVEL, PETER J · 2004 to 2008
$1.8M
Fatty acid sources of fructose and HFCS-induced postprandial hypertriglyceridemiaR01HL107256 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAVEL, PETER J, SCHWARZ, JEAN-MARC · 2011 to 2014
$1.5M
Prevention of Diabetes with Nutritional SupplementsR21AT002993 · NCCIH · UNIVERSITY OF CALIFORNIA DAVIS · PI HAVEL, PETER J · 2005 to 2007
$584k
NCCIH NIH HHS 1R21AT002993NCCIH NIH HHS 1R21AT003545NCCIH NIH HHS 5R21AT2500NCCIH NIH HHS R21 AT002993NCRR NIH HHS UL1 RR024146NHLBI NIH HHS R01 HL075675NHLBI NIH HHS R01 HL091333NHLBI NIH HHS R01 HL107256
6 · The paper itself

Abstract

backgroundWe have reported that, compared with glucose-sweetened beverages, consuming fructose-sweetened beverages with meals results in lower 24-h circulating glucose, insulin, and leptin concentrations and elevated triacylglycerol (TG). However, pure fructose and glucose are not commonly used as sweeteners. High-fructose corn syrup (HFCS) has replaced sucrose as the predominant sweetener in beverages in the United States.

objectiveWe compared the metabolic/endocrine effects of HFCS with sucrose and, in a subset of subjects, with pure fructose and glucose.

designThirty-four men and women consumed 3 isocaloric meals with either sucrose- or HFCS-sweetened beverages, and blood samples were collected over 24 h. Eight of the male subjects were also studied when fructose- or glucose-sweetened beverages were consumed.

resultsIn 34 subjects, 24-h glucose, insulin, leptin, ghrelin, and TG profiles were similar between days that sucrose or HFCS was consumed. Postprandial TG excursions after HFCS or sucrose were larger in men than in women. In the men in whom the effects of 4 sweeteners were compared, the 24-h glucose and insulin responses induced by HFCS and sucrose were intermediate between the lower responses during consumption of fructose and the higher responses during glucose. Unexpectedly, postprandial TG profiles after HFCS or sucrose were not intermediate but comparably high as after pure fructose.

conclusionsSucrose and HFCS do not have substantially different short-term endocrine/metabolic effects. In male subjects, short-term consumption of sucrose and HFCS resulted in postprandial TG responses comparable to those induced by fructose.

Indexed as

AdultArea Under CurveBeveragesBlood GlucoseCardiovascular DiseasesCross-Over StudiesDietary CarbohydratesFatty Acids, NonesterifiedFemaleFructoseGhrelinGlucoseHumansInsulinLeptinMaleBlood GlucoseDietary CarbohydratesFatty Acids, NonesterifiedFructoseGhrelinGlucoseInsulinLeptinSucroseTriglycerides

Identifiers

PMID18469239
PMCPMC3037416
OpenAlexW2124655674

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.