GLP-1 receptor agonists × glycemic control

TrialDiabetes research and clinical practice2008

Dose-dependent improvement in glycemia with once-daily liraglutide without hypoglycemia or weight gain: A double-blind, randomized, controlled trial in Japanese patients with type 2 diabetes.

Y Seino et al.PubMed ↗Publisher ↗

  • Liraglutide (dose not specified, but implied up to 0.9mg/day)looks good hereLower fasting blood sugar, no range given, lower postprandial glucose excursion, no range given, higher postprandial insulin secretion, no range given.No ranges given.

What the trial testedas reported · 2008

No range given

Reported lower fasting blood sugar, no range given

−2.50mmol/L

liraglutide (dose not specified, but implied up to 0.9mg/day) vs placebo

As reported

difference −2.50 mmol/L, no interval · the paper's word: fasting plasma glucose

No range given

Reported lower postprandial glucose excursion, no range given

−12.8

liraglutide (dose not specified, but implied up to 0.9mg/day) vs placebo

As reported

difference −12.8, no interval

No range given

Reported higher beta-cell function as evaluated by HOMA-beta, no range given

+20.0

liraglutide (dose not specified, but implied up to 0.9mg/day) vs placebo

As reported

difference 20.0, no interval

+1 more in the walkthrough ↓

Who was studied, and how

226people in the Effect of Liraglutide on Glycaemic Control in Japanese Subjects With Type 2 Diabetes. trial, from 2005
of them with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

liraglutide (dose not specified, but implied up to 0.9mg/day)
placebo

Reported lower fasting blood sugar, no range given−2.50

Reported lower postprandial glucose excursion, no range given−12.8

Reported higher postprandial insulin secretion, no range given+23.0

randomised

the abstract, start to end

placebo: fasting plasma glucose (up to 2.5mmol/L), postprandial (0-3h) glucose excursion (up to 12.8mmol/(Lh)); and increased postprandial insulin secretion (up to 23.0microU/(mLh)) and beta-cell function as evaluated by HOMA-beta (up to around 20.0(microU/mL)/(mg/dL)).

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
Fasting plasma glucoseliraglutide (dose not specified, but implied up to 0.9mg/day) vs placebo
−2.50
Postprandial (0-3h) glucose excursionliraglutide (dose not specified, but implied up to 0.9mg/day) vs placebo
−12.8
Postprandial insulin secretionliraglutide (dose not specified, but implied up to 0.9mg/day) vs placebo
23.0
Beta-cell function as evaluated by HOMA-betaliraglutide (dose not specified, but implied up to 0.9mg/day) vs placebo
20.0
GLP-1 receptor agonistsGlycemic control

GLP-1 receptor agonists × glycemic controlhelps?replicated

unlikelylikely
0.910.91 without it
← favours comparatorfavours treatment →
this papermore certainless certain
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The trial

Full record →Abstract, authors, funding and every citing paper · PMID 18495285