ArticleThe EMBO journal1991
The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins.
Article in The EMBO journal, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
What it found
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Who cites it
92 citing papers in PubMed, 373 citations in OpenAlex.
- Article
- Hyperglycemia, a neglected factor during cancer progression.BioMed research international · 2014Review
- Matrix metalloproteinase-9: Many shades of function in cardiovascular disease.Physiology (Bethesda, Md.) · 2013Review
- HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma.The Journal of clinical investigation · 2013Article
- Monomeric and dimeric models of ERK2 in conjunction with studies on cellular localization, nuclear translocation, and in vitro analysis.Molecules and cells · 2012Review
- Structural basis of Ets1 cooperative binding to widely separated sites on promoter DNA.PloS one · 2012Article
- Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA.Cell cycle (Georgetown, Tex.) · 2010Article
- The expression of ELK transcription factors in adult DRG: Novel isoforms, antisense transcripts and upregulation by nerve damage.Molecular and cellular neurosciences · 2010Article
- Ets1 induces dysplastic changes when expressed in terminally-differentiating squamous epidermal cells.PloS one · 2009Article
- Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization.The EMBO journal · 2008Article
- Adeno-associated virus vector-mediated production of hepatocyte growth factor attenuates liver fibrosis in mice.Hepatology international · 2008Article
- Suppressive activity of tiotropium bromide on matrix metalloproteinase production from lung fibroblasts in vitro.International journal of chronic obstructive pulmonary disease · 2008Article
- The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription.Nucleic acids research · 2007Article
- Matrix metalloproteinase-1 up-regulation by hepatocyte growth factor in human dermal fibroblasts via ERK signaling pathway involves Ets1 and Fli1.Nucleic acids research · 2005Article
- Suppression of matrix metalloproteinase-9 production from neutrophils by a macrolide antibiotic, roxithromycin, in vitro.Mediators of inflammation · 2004Article
- Interleukin-4 suppresses IL-1-induced expression of matrix metalloproteinase-3 in human gingival fibroblasts.Journal of periodontology · 2004Article
- Drosophila screening model for metastasis: Semaphorin 5c is required for l(2)gl cancer phenotype.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Ets-1 gene expression in patients with thymoma.The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi · 2002Article
- Sp100 interacts with ETS-1 and stimulates its transcriptional activity.Molecular and cellular biology · 2002Article
- Pituitary Ets-1 and GABP bind to the growth factor regulatory sites of the rat prolactin promoter.Nucleic acids research · 2001Article
32 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The c-ets protooncogenes have recently been shown to code for transcription factors that activate the oncogene responsive unit of the polyoma virus enhancer. We show that transcription of the stromelysin gene, which is highly expressed in transformed cells and tumours, is efficiently activated by c-Ets-1 and -2 through two DNA elements. The distal element is a highly conserved palindrome composed of two strong binding sites for c-Ets-1. The proximal element does not bind c-Ets-1, but may be activated indirectly by increased synthesis of c-Jun and c-Fos. Both ets responsive elements mediate activation by the oncoproteins Ha-Ras, v-Src and v-Mos. These results suggest that c-Ets participates in the mechanisms by which stromelysin gene expression is deregulated in transformed cells and tumours.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.