Intensive glycemic control in the ACCORD and ADVANCE trials.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

113 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Psychological interventions to improve self-management of type 1 and type 2 diabetes: a systematic review.Health technology assessment (Winchester, England) · 2020
   Pooled it
2. Intensive versus standard blood pressure control in type 2 diabetes: a restricted mean survival time analysis of a randomised controlled trial.BMJ open · 2021
   Trial
3. Benefits of insulin degludec/liraglutide are maintained even in patients discontinuing sulphonylureas or dipeptidyl peptidase-4 inhibitors upon initiation of degludec/liraglutide therapy: A post hoc analysis of the DUAL II and DUAL IX trials.Diabetes, obesity & metabolism · 2020
   Trial
4. Effect of Food on the Pharmacokinetics of Saroglitazar Magnesium, a Novel Dual PPARαγ Agonist, in Healthy Adult Subjects.Clinical drug investigation · 2018
   Trial
5. Insulin Dose and Cardiovascular Mortality in the ACCORD Trial.Diabetes care · 2015
   Trial
6. Mexican American trial of community health workers: a randomized controlled trial of a community health worker intervention for Mexican Americans with type 2 diabetes mellitus.American journal of public health · 2014
   Trial
7. The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus.Cardiovascular diabetology · 2014 · on this map
   Trial
8. Pharmacokinetics, safety, and tolerability of saroglitazar (ZYH1), a predominantly PPARα agonist with moderate PPARγ agonist activity in healthy human subjects.Clinical drug investigation · 2013
   Trial
9. Comparison of vildagliptin twice daily vs. sitagliptin once daily using continuous glucose monitoring (CGM): crossover pilot study (J-VICTORIA study).Cardiovascular diabetology · 2012
   Trial
10. Biophysiologic outcomes of the Enhancing Adherence in Type 2 Diabetes (ENHANCE) trial.Journal of the Academy of Nutrition and Dietetics · 2012
    Trial
11. Renal function in type 2 diabetes with rosiglitazone, metformin, and glyburide monotherapy.Clinical journal of the American Society of Nephrology : CJASN · 2011
    Trial
12. Randomized clinical trial of quick-release bromocriptine among patients with type 2 diabetes on overall safety and cardiovascular outcomes.Diabetes care · 2010
    Trial
13. Epidemiologic relationships between A1C and all-cause mortality during a median 3.4-year follow-up of glycemic treatment in the ACCORD trial.Diabetes care · 2010
    Trial
14. Effect of intensive compared with standard glycemia treatment strategies on mortality by baseline subgroup characteristics: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.Diabetes care · 2010
    Trial
15. Exenatide compared with long-acting insulin to achieve glycaemic control with minimal weight gain in patients with type 2 diabetes: results of the Helping Evaluate Exenatide in patients with diabetes compared with Long-Acting insulin (HEELA) study.Diabetes, obesity & metabolism · 2009
    Trial
16. A randomized trial comparing telemedicine case management with usual care in older, ethnically diverse, medically underserved patients with diabetes mellitus: 5 year results of the IDEATel study.Journal of the American Medical Informatics Association : JAMIA
    Trial
17. Impact of electronic health record clinical decision support on diabetes care: a randomized trial.Annals of family medicine
    Trial
18. Effect of hypoglycemia on the diameter of cerebral vasculature in vivo and cerebral ischemia-reperfusion injury in mice.Experimental neurology · 2026
    Article
19. Mechanisms of diabetic kidney disease and established and emerging treatments.Nature reviews. Endocrinology · 2026
    Review
20. Alpha-ketoglutarate rescues impaired endothelial progenitor cell-mediated angiogenesis in diabetic mice.Frontiers in pharmacology · 2025
    Article

53 more citing papers are in PubMed but not listed here.

Corrections and comments

• Comment on
  Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.2008
• Comment on
  Effects of intensive glucose lowering in type 2 diabetes.2008

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as