← Cardiac procedures & devices × glycemic control

TrialObesity (Silver Spring, Md.)2008

Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test.

Ravi Retnakaran et al.PubMed ↗Publisher ↗

Product of AUC(ins/gluc) and Matsuda indexlooks good hereLower product of AUC and Matsuda index.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Product of AUC(ins/gluc) and Matsuda index went with lower product of AUC and Matsuda index

−212

product of AUC(ins/gluc) and Matsuda index, in NGT

As reported

difference −212, no interval

Correlation, not cause

Product of AUC(ins/gluc) and Matsuda index went with lower product of AUC and Matsuda index

−193

product of AUC(ins/gluc) and Matsuda index, in IGT

As reported

difference −193, no interval

Correlation, not cause

Product of AUC(ins/gluc) and Matsuda index went with lower product of AUC and Matsuda index

−104

product of AUC(ins/gluc) and Matsuda index, in diabetes

As reported

difference −104, no interval

Who was studied, and how

404people with type 2 diabetes, in this paper

Already taking product of AUC(ins/gluc) and Matsuda index, or nottheir own situation, not assigned

on product of AUC(ins/gluc) and Matsuda index

not on product of AUC(ins/gluc) and Matsuda index

Product of AUC(ins/gluc) and Matsuda index went with lower product of AUC and Matsuda index−212

correlation, not a test

the abstract, start to end

… index progressively decreased from NGT (212) to IGT (193) to diabetes (104) (P < 0.001), consistent with …

← favours treatmentfavours comparator →

could be chance

No interval given · direction only, strength unknown

Product of AUC(ins/gluc) and Matsuda indexproduct of AUC(ins/gluc) and Matsuda index, in NGT

−212

Product of AUC(ins/gluc) and Matsuda indexproduct of AUC(ins/gluc) and Matsuda index, in IGT

−193

Product of AUC(ins/gluc) and Matsuda indexproduct of AUC(ins/gluc) and Matsuda index, in diabetes

−104

Cardiac procedures & devicesGlycemic control

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160 papers cite itlatest 60 shown

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this paperpooled ittrialcites it

The trial

NCT02437084phase 4115 enrolled2015

Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test.

What moved togetherboth groups pooled, not the treatment’s effect

Product of AUC(ins/gluc) and Matsuda index went with lower product of AUC and Matsuda index

Product of AUC(ins/gluc) and Matsuda index went with lower product of AUC and Matsuda index

Product of AUC(ins/gluc) and Matsuda index went with lower product of AUC and Matsuda index

Who was studied, and how

Three numbers in the abstract

Where each one falls

Where it lands on the map

160 papers cite itlatest 60 shown

The trial