ArticleJournal of applied toxicology : JAT2008
Pentachlorophenol decreases ATP levels in human natural killer cells.
Article in Journal of applied toxicology : JAT, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- Exposures to the environmental toxicants pentachlorophenol (PCP) and dichlorodiphenyltrichloroethane (DDT) modify secretion of interleukin 1-beta (IL-1β) from human immune cells.Archives of toxicology · 2017Article
- Effects of pentachlorophenol and dichlorodiphenyltrichloroethane on secretion of interferon gamma (IFNγ) and tumor necrosis factor alpha (TNFα) from human immune cells.Toxicology mechanisms and methods · 2017Article
- Inhibition of cellular efflux pumps involved in multi xenobiotic resistance (MXR) in echinoid larvae as a possible mode of action for increased ecotoxicological risk of mixtures.Ecotoxicology (London, England) · 2012Article
- Pentachlorophenol decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells.Journal of applied toxicology : JAT · 2012Article
- Tetrabromobisphenol A has immunosuppressive effects on human natural killer cells.Journal of immunotoxicology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Pentachlorophenol (PCP) is used as a wood preservative and is found in human blood and urine. PCP causes significant decreases in the tumor-killing (lytic) function of human natural killer (NK) cells, a critical immune defense. The current study examined the association between decreased lytic function and decreased ATP levels, as well as the ability of antioxidants (vitamin E and reduced glutathione) to prevent PCP-induced decreases in either ATP levels or lytic function. Exposure of NK cells to 10 microm PCP decreased ATP levels by 15% at 24 h, and exposure to 5 microm PCP decreased ATP levels by 32% at 48 h. No effects were seen with 0.5 microm at 48 h or with 5 microm at 24 h. However, 10 microm PCP decreased lytic function by 69% at 24 h and 5 microm decreased it by 90% at 48 h. Even 0.5 microm PCP decreased lytic function by 46% at 48 h. None of these effects were prevented by pretreatment with 1 mm vitamin E or reduced glutathione.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.