ReviewDiabetes & metabolism2008
Beta-cell apoptosis in type 2 diabetes: quantitative and functional consequences.
Review in Diabetes & metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04131582 (Effect of a Quadruple Therapy on Pancreatic Islet Function, Insulin Resistance and Cardiovascular Function in Patients With Mixed Prediabetes and Obesity), which is not on this map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of a Quadruple Therapy on Pancreatic Islet Function, Insulin Resistance and Cardiovascular Function in Patients With Mixed Prediabetes and Obesity: Randomized Clinical Trial
Who cites it
32 citing papers in PubMed, 87 citations in OpenAlex.
- Malvidin-3-glucoside induces insulin secretion by activating the PLC/IPScientific reports · 2025Article
- Cdk5 mediates impaired autophagy by regulating NGF/Sirt1 axis to cause diabetic islet β cell damage.Frontiers in cell and developmental biology · 2025Article
- Identification of Potential Plant-Derived Pancreatic Beta-Cell-Directed Agents Using New Custom-Designed Screening Method:Molecules (Basel, Switzerland) · 2023Review
- Rhein for treating diabetes mellitus: A pharmacological and mechanistic overview.Frontiers in pharmacology · 2022Review
- Effect of free fatty acids on insulin secretion, insulin sensitivity and incretin effect - a narrative review.Archives of endocrinology and metabolism · 2021Review
- Beta-Cell Dysfunction Induced by Tacrolimus: A Way to Explain Type 2 Diabetes?International journal of molecular sciences · 2021Review
- IRS-2/Akt/GSK-3Oxidative medicine and cellular longevity · 2021Article
- Chitosan Oligosaccharides Attenuate Amyloid Formation of hIAPP and Protect Pancreatic β-Cells from Cytotoxicity.Molecules (Basel, Switzerland) · 2020Article
- Danzhi Jiangtang Capsule Mediates NIT-1 Insulinoma Cell Proliferation and Apoptosis by GLP-1/Akt Signaling Pathway.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- A novel polysaccharide fromFood & nutrition research · 2019Article
- Effect of gastric bypass combined with ileal transportation on type 2 diabetes mellitus.Experimental and therapeutic medicine · 2018Article
- Five-Year Predictors of Insulin Initiation in People with Type 2 Diabetes under Real-Life Conditions.Journal of diabetes research · 2018Article
- Article
- Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes.Molecular metabolism · 2017Article
- Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas).Diabetologia · 2015Article
- Sesamin Ameliorates Advanced Glycation End Products-Induced Pancreatic β-Cell Dysfunction and Apoptosis.Nutrients · 2015Article
- Targeting metabolic disorders by natural products.Journal of diabetes and metabolic disorders · 2015Article
- Systematic investigation into the role of intermittent high glucose in pancreatic beta-cells.International journal of clinical and experimental medicine · 2015Article
- Assay development and multivariate scoring for high-content discovery of chemoprotectants of endoplasmic-reticulum-stress-mediated amylin-induced cytotoxicity in pancreatic beta cells.Assay and drug development technologies · 2014Article
- Pancreatic β cell dedifferentiation in diabetes and redifferentiation following insulin therapy.Cell metabolism · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes, the most common form of diabetes in humans, is characterized by impaired insulin secretion paralleled by a progressive decline in beta-cell function and chronic insulin resistance. Several authors have showed that in type 2 diabetes there is a reduction of islet and/or insulin-containing cell mass or volume. Regulation of the beta-cell mass appears to involve a balance of beta-cell replication and apoptosis but, at the molecular level, pancreatic beta-cell loss by apoptosis appears to play an important role in the development of insulin deficiency and the onset and/or progression of the disease. The mechanisms favoring apoptosis in type 2 diabetic pancreatic islets and new potential therapeutic approaches to prevent beta-cell death and maintain beta-cell mass are discussed.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.