ArticleMarine biotechnology (New York, N.Y.)
Inhibitory effect of deep-sea water on differentiation of 3T3-L1 adipocytes.
Article in Marine biotechnology (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Drinking deep seawater decreases serum total and low-density lipoprotein-cholesterol in hypercholesterolemic subjects.Journal of medicinal food · 2012Trial
- Deep Sea Minerals Ameliorate Dermatophagoides Farinae- or 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-like Skin Lesions in NC/Nga Mice.Biomedicines · 2025Article
- Magnesium-enriched deep-sea water inhibits NLRP3 inflammasome activation and dampens inflammation.Heliyon · 2024Article
- Immunostimulatory Effects of Korean Mineral-Rich Seawaters on Cyclophosphamide-Induced Immunosuppression in Mice.Marine drugs · 2024Article
- Deep Sea Water Inhibited Pancreatic β-Cell Apoptosis and Regulated Glucose Homeostasis by Affecting Lipid Metabolism in Db/Db Mice.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Mineral-rich Jeju lava sea water suppresses lipid accumulation in 3T3-L1 adipocytes and ameliorates high-fat diet-induced obesity in C57BL/6 J mice.Food science and biotechnology · 2021Article
- Combination Treatment of Deep Sea Water and Fucoidan Attenuates High Glucose-Induced Insulin-Resistance in HepG2 Hepatocytes.Marine drugs · 2018Article
- Deep Sea Water Improves Abnormalities in Lipid Metabolism through Lipolysis and Fatty Acid Oxidation in High-Fat Diet-Induced Obese Rats.Marine drugs · 2017Article
- Stimulatory Effect of Balanced Deep-Sea Water Containing Chitosan Oligosaccharides on Glucose Uptake in C2C12 Myotubes.Marine biotechnology (New York, N.Y.) · 2016Article
- Combination of deep sea water andExperimental and therapeutic medicine · 2016Article
- Potential Health Benefits of Deep Sea Water: A Review.Evidence-based complementary and alternative medicine : eCAM · 2016Review
- Effect of the salts of deep ocean water on the production of cordycepin and adenosine of Cordyceps militaris-fermented product.AMB Express · 2015Article
- Modulation of lipid metabolism by deep-sea water in cultured human liver (HepG2) cells.Marine biotechnology (New York, N.Y.) · 2014Article
- Anti-diabetic effect of balanced deep-sea water and its mode of action in high-fat diet induced diabetic mice.Marine drugs · 2013Article
- Enhanced anti-obesity activities of red mold dioscorea when fermented using deep ocean water as the culture water.Marine drugs · 2013Article
- Enhancement of immune activation activities of Spirulina maxima grown in deep-sea water.International journal of molecular sciences · 2013Article
- Desalinated underground seawater of Jeju Island (Korea) improves lipid metabolism in mice fed diets containing high fat and increases antioxidant potential in t-BHP treated HepG2 cells.Nutrition research and practice · 2010Article
- Anti-obesity and antidiabetic effects of deep sea water on ob/ob mice.Marine biotechnology (New York, N.Y.)Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently, the utilization of deep-sea water (DSW) is receiving much attention due to its high productivity, large quantity, and potential for biological application. The 3T3-L1 cell line is a well-established and commonly used in vitro model to assess adipocyte differentiation. Over the course of several days, confluent 3T3-L1 cells can be converted to adipocytes in the presence of an adipogenic cocktail. In this study, the effects of DSW on differentiation adipocyte 3T3-L1 cells were studied. DSW significantly decreased lipid accumulation, a marker of adipogenesis, in a dose-dependent manner. DSW of hardness 1,000 was the most effective for inhibiting adipocyte differentiation without any cytotoxicity. DSW significantly reduced expression mRNA levels of PPARgamma and C/EBPalpha and protein levels of fatty-acid-binding protein and adiponectin. Our results suggest a potential role for DSW as anti-obesity agents by inhibiting adipocyte differentiation mediated through the down-regulated expression of adipogenic transcription factors and adipocyte-specific proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.