ArticleJournal of magnetic resonance imaging : JMRI2008
Transit delay and flow quantification in muscle with continuous arterial spin labeling perfusion-MRI.
Article in Journal of magnetic resonance imaging : JMRI, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Combined measurement of perfusion, venous oxygen saturation, and skeletal muscle T2* during reactive hyperemia in the leg.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2013Trial
- Perfusion Signal Analysis Using Multi-pulsed Arterial Spin Labeling (mPASL) with Multiple Post-labeling Delays: Phantom Validation and Application to the Human Foot.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Article
- Intravoxel Incoherent Motion Magnetic Resonance Imaging in Skeletal Muscle: Review and Future Directions.Journal of magnetic resonance imaging : JMRI · 2022Review
- Exercise-stimulated arterial transit time in calf muscles measured by dynamic contrast-enhanced magnetic resonance imaging.Physiological reports · 2019Article
- Exercise-induced calf muscle hyperemia: quantitative mapping with low-dose dynamic contrast enhanced magnetic resonance imaging.American journal of physiology. Heart and circulatory physiology · 2019Article
- Evaluation of three-dimensional arterial spin labeling perfusion imaging for the pathological investigation of musculoskeletal tumors.Experimental and therapeutic medicine · 2018Article
- Evaluation of skeletal muscle microvascular perfusion of lower extremities by cardiovascular magnetic resonance arterial spin labeling, blood oxygenation level-dependent, and intravoxel incoherent motion techniques.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2018Article
- Simultaneous measurement of macro- and microvascular blood flow and oxygen saturation for quantification of muscle oxygen consumption.Magnetic resonance in medicine · 2018Article
- Measurement of skeletal muscle perfusion dynamics with pseudo-continuous arterial spin labeling (pCASL): Assessment of relative labeling efficiency at rest and during hyperemia, and comparison to pulsed arterial spin labeling (PASL).Journal of magnetic resonance imaging : JMRI · 2016Article
- Increased SNR efficiency in velocity selective arterial spin labeling using multiple velocity selective saturation modules (mm-VSASL).Magnetic resonance in medicine · 2015Article
- Matching of postcontraction perfusion to oxygen consumption across submaximal contraction intensities in exercising humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Multiparametric assessment of vascular function in peripheral artery disease: dynamic measurement of skeletal muscle perfusion, blood-oxygen-level dependent signal, and venous oxygen saturation.Circulation. Cardiovascular imaging · 2015Article
- A pilot study of regional perfusion and oxygenation in calf muscles of individuals with diabetes with a noninvasive measure.Journal of vascular surgery · 2014Article
- Temporal course of perfusion in human masseter muscle during isometric contraction assessed by arterial spin labeling at 3T.Magma (New York, N.Y.) · 2011Article
- Evaluation of cuff-induced ischemia in the lower extremity by magnetic resonance oximetry.Journal of the American College of Cardiology · 2010Article
- Detection of lactate with a hadamard slice selected, selective multiple quantum coherence, chemical shift imaging sequence (HDMD-SelMQC-CSI) on a clinical MRI scanner: Application to tumors and muscle ischemia.Magnetic resonance in medicine · 2009Article
- Skeletal muscle microvascular flow in progressive peripheral artery disease: assessment with continuous arterial spin-labeling perfusion magnetic resonance imaging.Journal of the American College of Cardiology · 2009Article
- Hyperemic flow heterogeneity within the calf, foot, and forearm measured with continuous arterial spin labeling MRI.American journal of physiology. Heart and circulatory physiology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo test the hypothesis that flow measurements using continuous arterial spin labeling (CASL) magnetic resonance imaging (MRI) in muscle depend upon transit delay, and examine the repeatability of CASL measurements. MATERIALS AND
methodsA total of 23 healthy subjects underwent CASL imaging of the calf, foot, and forearm with varying postlabeling delay (PLD = 1000, 1500, and 1900 msec). Experiments were conducted on a 3.0T system. An orthopedic tourniquet system was employed to create a five-minute period of ischemia followed by a transient hyperemic flow. Imaging commenced two minutes prior to cuff inflation and ended three minutes after cuff release.
resultsCASL was found able to well resolve the time course of the hyperemic flow pattern with an effective TR of 16 seconds, although we were unable to establish that a plateau had been reached in the flow measurements even at a PLD as long as 1900 msec. Peak hyperemic flow measurements compared favorably with those obtained with contrast-enhanced (CE) MRI following a similar period of ischemia. Region-of-interest (ROI)-based repeated measurements varied by approximately 20% over a period of one hour.
conclusionIn all anatomic regions studied, flow measurements were found to increase with PLD, suggesting the prolonged transit delay in muscle.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.