Statins × blood pressure

TrialThe American journal of cardiology2008

Effects of adding prescription omega-3 acid ethyl esters to simvastatin (20 mg/day) on lipids and lipoprotein particles in men and women with mixed dyslipidemia.

Kevin C Maki et al.PubMed ↗Publisher ↗

  • P-OM3 + simvastatinlooks good hereLower systolic blood pressure, no range given, lower diastolic blood pressure, no range given.No ranges given.

What the trial testedas reported · 39 people · 2008

No range given

Reported lower systolic blood pressure, no range given

−5.00

P-OM3 + simvastatin vs placebo + simvastatin

As reported

difference −5.0, no interval

No range given

Reported lower diastolic blood pressure, no range given

−3.30

P-OM3 + simvastatin vs placebo + simvastatin

As reported

difference −3.3, no interval

Who was studied, and how

40people in the An Evaluation of Simvastatin 20 mg Plus Omacor 4 g Compared to Simvastatin 20 mg Plus Placebo in Subjects With Mixed Dyslipidemia trial, from 2006
39of them with dyslipidemia, in this paper

The trial randomly assignedassigned by chance

P-OM3 + simvastatin
placebo + simvastatin

Reported lower systolic blood pressure, no range given−5.00

Reported lower diastolic blood pressure, no range given−3.30

randomised

the abstract, start to end

ratio (-51% vs -37%), and systolic (-5.0 vs 0.3 mm Hg) and diastolic (-3.3 vs -1.8 mm Hg) blood pressures

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
Systolic blood pressureP-OM3 + simvastatin vs placebo + simvastatin
−5.0
Diastolic blood pressureP-OM3 + simvastatin vs placebo + simvastatin
−3.3
StatinsBlood pressure

Statins × blood pressurehelps?replicated

unlikelylikely
0.830.80 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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23 papers cite it

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The trial

Full record →Abstract, authors, funding and every citing paper · PMID 18678300