ArticleCritical reviews in toxicology2008
Awareness of hormesis will enhance future research in basic and applied neuroscience.
Article in Critical reviews in toxicology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 80 citations in OpenAlex.
- The centenarian blueprint: lessons in defying Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Elucidating individual differences in chronic pain and whole person health with allostatic load biomarkers.Brain, behavior, & immunity - health · 2023Article
- Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases.Immunity & ageing : I & A · 2022Review
- PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer's Disease.Current neuropharmacology · 2022Review
- Are Alzheimer's and coronary artery diseases genetically related to longevity?Frontiers in psychiatry · 2022Article
- Reconceptualization of Hormetic Responses in the Frame of Redox Toxicology.International journal of molecular sciences · 2021Review
- Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling.Cell death & disease · 2019Article
- Conditioning Against the Pathology of Parkinson's disease.Conditioning medicine · 2018Article
- Mitochondrial fragmentation affects neither the sensitivity to TNFα-induced apoptosis of Brucella-infected cells nor the intracellular replication of the bacteria.Scientific reports · 2018Article
- Dominant and opponent relations in cortical function: An EEG study of exam performance and stress.AIMS neuroscience · 2018Article
- The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates.Frontiers in medicine · 2018Review
- Impacts of Early Life Stress on the Methylome and Transcriptome of Atlantic Salmon.Scientific reports · 2017Article
- Risk assessment for human health in a seleniferous area, Shuang'an, China.Environmental science and pollution research international · 2017Article
- Brain metabolism in health, aging, and neurodegeneration.The EMBO journal · 2017Review
- Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways.Redox biology · 2017Article
- Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways.Scientific reports · 2017Article
- Nutritional Ketosis Affects Metabolism and Behavior in Sprague-Dawley Rats in Both Control and Chronic Stress Environments.Frontiers in molecular neuroscience · 2017Article
- Hormesis: Decoding Two Sides of the Same Coin.Pharmaceuticals (Basel, Switzerland) · 2015Review
- Neurohormetic phytochemicals: An evolutionary-bioenergetic perspective.Neurochemistry international · 2015Review
- Aged rats are hypo-responsive to acute restraint: implications for psychosocial stress in aging.Frontiers in aging neuroscience · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Hormesis is defined operationally as responses of cells or organisms to an exogenous or intrinsic factor (chemical, temperature, psychological challenge, etc.) in which the factor induces stimulatory or beneficial effects at low doses and inhibitory or adverse effects at high doses. The compendium of articles by Calabrese entitled "Neuroscience and Hormesis" provides a broad range of examples of neurobiological processes and responses to environmental factors that exhibit biphasic dose responses, the signature of hormesis. Nerve cell networks are the "first responders" to environmental challenges--they perceive the challenge and orchestrate coordinated adaptive responses that typically involve autonomic, neuroendocrine, and behavioral changes. In addition to direct adaptive responses of neurons to environmental stressors, cells subjected to a stressor produce and release molecules such as growth factors, cytokines, and hormones that alert adjacent and even distant cells to impending danger. The discoveries that some molecules (e.g., carbon monoxide and nitric oxide) and elements (e.g., selenium and iron) that are toxic at high doses play fundamental roles in cellular signaling or metabolism suggest that during evolution, organisms (and their nervous systems) co-opted environmental toxins and used them to their advantage. Neurons also respond adaptively to everyday stressors, including physical exercise, cognitive challenges, and dietary energy restriction, each of which activates pathways linked to the production of neurotrophic factors and cellular stress resistance proteins. The development of interventions that activate hormetic signaling pathways in neurons is a promising new approach for the preventation and treatment of a range of neurological disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.