UKPDS and the legacy effect.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

114 citing papers in PubMed, 3 syntheses or guidelines pooled it.

1. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
   Guideline
2. Legacy effects of statins on cardiovascular and all-cause mortality: a meta-analysis.BMJ open · 2018 · on this map
   Pooled it
3. Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes.Diabetes · 2011
   Pooled it
4. Efficacy and safety of a fixed-dose combination of dapagliflozin and linagliptin (AJU-A51) in patients with type 2 diabetes mellitus: A multicentre, randomized, double-blind, parallel-group, placebo-controlled phase III study.Diabetes, obesity & metabolism · 2025 · on this map
   Trial
5. Non-diabetes status after diagnosis of impaired glucose tolerance and risk of long-term death and vascular complications: A post hoc analysis of the Da Qing Diabetes Prevention Outcome Study.PLoS medicine · 2024
   Trial
6. A randomized controlled trial examining the effects of behavioral weight loss treatment on hippocampal volume and neurocognition.Physiology & behavior · 2023
   Trial
7. Insulin secretion is a strong predictor for need of insulin therapy in patients with new-onset diabetes and HbA1c of more than 10%: A post hoc analysis of the EDICT study.Diabetes, obesity & metabolism · 2021
   Trial
8. Decreased diabetes risk over 9 year after 18-month oral L-arginine treatment in middle-aged subjects with impaired glucose tolerance and metabolic syndrome (extension evaluation of L-arginine study).European journal of nutrition · 2018
   Trial
9. A pragmatic lifestyle modification programme reduces the incidence of predictors of cardio-metabolic disease and dysglycaemia in a young healthy urban South Asian population: a randomised controlled trial.BMC medicine · 2017
   Trial
10. Effect of a Long-Term Intensive Lifestyle Intervention on Cognitive Function: Action for Health in Diabetes Study.Journal of the American Geriatrics Society · 2017
    Trial
11. Effect of Erythropoietin in patients with acute myocardial infarction: five-year results of the REVIVAL-3 trial.BMC cardiovascular disorders · 2017
    Trial
12. Head-to-head comparison of intensive lifestyle intervention (U-TURN) versus conventional multifactorial care in patients with type 2 diabetes: protocol and rationale for an assessor-blinded, parallel group and randomised trial.BMJ open · 2015
    Trial
13. Mortality benefit of participation in BOOCS program: a follow-up study for 15 years in a Japanese working population.Journal of occupational and environmental medicine · 2015
    Trial
14. A Modified Delphi consensus on early management of combined cardiovascular risk factors in adult patients with type 2 diabetes in Italy.Acta diabetologica · 2026
    Article
15. Clinical characteristics and intensification patterns in subjects with "early" type 2 diabetes in Italy- an analysis from the AMD annals initiative.Acta diabetologica · 2026
    Article
16. Adenosine Monophosphate-Activated Protein Kinase Activation and Mammalian Target of Rapamycin Complex 1 Inhibition: A Mechanistic Rationale for Anti-Aging Therapy in Type 2 Diabetes.Journal of clinical medicine research · 2025
    Review
17. The Timeline of the Association Between Diabetes and Cardiovascular Diseases: A Narrative Review.Journal of clinical medicine · 2025
    Review
18. Association of Antidiabetic Medication Regimens and Medication Adherence With HbA1c Reduction in Type 2 Diabetic Patients: A Retrospective Study.Cureus · 2025
    Article
19. Emerging uncertainty on the anti-aging potential of metformin.Ageing research reviews · 2025
    Review
20. When Does Metabolic Memory Start? Insights From the Association of Medical Diabetologists Annals Initiative on Stringent HbA1c Targets.Diabetes · 2025
    Article

54 more citing papers are in PubMed but not listed here.

Corrections and comments

• Comment on
  10-year follow-up of intensive glucose control in type 2 diabetes.2008
• Comment on
  Long-term follow-up after tight control of blood pressure in type 2 diabetes.2008

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as