ArticleJournal of virology1991
Sequence-specific interaction of the Ets1 protein with the long terminal repeat of the human T-lymphotropic virus type I.
Article in Journal of virology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 76 citations in OpenAlex.
- ETS1 Function in Leukemia and Lymphoma.Advances in experimental medicine and biology · 2024Review
- Article
- Activation of the human T-cell leukemia virus type 1 long terminal repeat by the ternary complex factor Elk-1.Journal of virology · 2007Article
- The high-affinity Sp1 binding site in the HTLV-1 promoter contributes to Tax-independent basal expression.Nucleic acids research · 2004Article
- GLI-2 modulates retroviral gene expression.Journal of virology · 2001Article
- HUB1, a novel Krüppel type zinc finger protein, represses the human T cell leukemia virus type I long terminal repeat-mediated expression.Nucleic acids research · 1997Article
- Human alpha-galactosidase A: high plasma activity expressed by the -30G-->A allele.Journal of inherited metabolic disease · 1997Article
- DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Function of the human T-cell leukemia virus type 1 21-base-pair repeats in basal transcription.Journal of virology · 1997Article
- Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1.Molecular and cellular biology · 1996Article
- Transcription of the human T-cell lymphotropic virus type I promoter by an alpha-amanitin-resistant polymerase.Journal of virology · 1994Article
- Subtype analysis of HTLV-1 in patients with HTLV-1 uveitis.Japanese journal of cancer research : Gann · 1994Article
- ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development.Molecular and cellular biology · 1994Article
- DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma.Molecular and cellular biology · 1994Article
- Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression.Journal of virology · 1994Article
- Transcriptional activation of the human T-lymphotropic virus type I long terminal repeat by functional interaction of Tax1 and Ets1.Journal of virology · 1993Article
- Pi, a pre-B-cell-specific enhancer element in the immunoglobulin heavy-chain enhancer.Molecular and cellular biology · 1993Article
- Transactivation of the P2 promoter of parathyroid hormone-related protein by human T-cell lymphotropic virus type I Tax1: evidence for the involvement of transcription factor Ets1.Journal of virology · 1993Article
- Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene products.Molecular and cellular biology · 1993Article
- Characterization of a hepatoma mRNA transcribed from a third promoter of a 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-encoding gene and controlled by ets oncogene-related products.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We recently demonstrated that members of the c-ets proto-oncogene family, Ets1 and Ets2, are sequence-specific transcriptional activators of the human T-lymphotropic virus type I (HTLV-I) long terminal repeat (LTR). We now report that the HTLV-I LTR contains two distinct Ets1-responsive regions, ERR-1 and ERR-2. Expression of Ets1 with reporter plasmids containing ERR-1 or ERR-2 upstream of a basal promoter resulted in an increase in transcriptional activity. By gel mobility shift assay, the interaction of Ets1 with the downstream ERR-1-binding region was found to be more stable than its interaction with the upstream ERR-2 region. By DNase I footprint, gel mobility shift, and methylation interference analyses, ERR-1 was found to contain two Ets1 binding sites, ERE-A and ERE-B. A recombinant Ets1 protein was found to bind with higher affinity to ERE-A than to ERE-B. Binding of Ets1 to these sites appears to result in a specific and sequential protection of a 37-nucleotide sequence of the HTLV-I LTR from -154 to -118. In view of the high-level expression of Ets1 in lymphoid cells, the c-ets proto-oncogenes encode transcription factors which could play an important role in both basal and Tax1-mediated HTLV-I transcription.
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