ArticleToxicology and applied pharmacology2009
Alterations in glucocorticoid negative feedback following maternal Pb, prenatal stress and the combination: a potential biological unifying mechanism for their corresponding disease profiles.
Article in Toxicology and applied pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Lead exposure, glucocorticoids, and physiological stress across the life course: A systematic review.Environmental pollution (Barking, Essex : 1987) · 2024Pooled it
- Associations between metal exposure and metabolic syndrome: exploring the mediating role of biological ageing among US adults.Diabetology & metabolic syndrome · 2025Article
- Do not exclude your observations: Negative cortisol awakening responses (CAR) may be biologically relevant.Psychoneuroendocrinology · 2025Article
- Metal mixtures and adiposity indicators in women from Northern Mexico.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Associations of prenatal and childhood Pb exposure with allostatic load in adolescence: Findings from the ELEMENT cohort study.Environmental research · 2023Article
- Metal Homeostasis and Exposure in Distinct Phenotypic Subtypes of Insulin Resistance among Children with Obesity.Nutrients · 2023Article
- Longitudinal association of early childhood lead exposure and adolescent heart rate variability: influence of parental education.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2022Article
- The Effect of Whole Blood Lead (Pb-B) Levels on Changes in Peripheral Blood Morphology and Selected Biochemical Parameters, and the Severity of Depression in Peri-Menopausal Women at Risk of Metabolic Syndrome or with Metabolic Syndrome.International journal of environmental research and public health · 2020Article
- Methods for Evaluating the Combined Effects of Chemical and Nonchemical Exposures for Cumulative Environmental Health Risk Assessment.International journal of environmental research and public health · 2018Article
- Developmental Lead Exposure and Prenatal Stress Result in Sex-Specific Reprograming of Adult Stress Physiology and Epigenetic Profiles in Brain.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Endocrine active metals, prenatal stress and enhanced neurobehavioral disruption.Hormones and behavior · 2018Article
- Sex-Dependent Effects of Developmental Lead Exposure on the Brain.Frontiers in genetics · 2018Review
- Developmental Lead and/or Prenatal Stress Exposures Followed by Different Types of Behavioral Experience Result in the Divergence of Brain Epigenetic Profiles in a Sex, Brain Region, and Time-Dependent Manner: Implications for Neurotoxicology.Current opinion in toxicology · 2017Article
- Lead Exposure Induces Weight Gain in Adult Rats, Accompanied by DNA Hypermethylation.PloS one · 2017Article
- Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice.Bone research · 2017Article
- This can't be stressed enough: The contribution of select environmental toxicants to disruption of the stress circuitry and response.Physiology & behavior · 2016Review
- Developmental stress and lead (Pb): Effects of maternal separation and/or Pb on corticosterone, monoamines, and blood Pb in rats.Neurotoxicology · 2016Article
- Longitudinal associations of age and prenatal lead exposure on cortisol secretion of 12-24 month-old infants from Mexico City.Environmental health : a global access science source · 2016Article
- Mercury and psychosocial stress exposure interact to predict maternal diurnal cortisol during pregnancy.Environmental health : a global access science source · 2015Article
- Multifactorial Origin of Neurodevelopmental Disorders: Approaches to Understanding Complex Etiologies.Toxics · 2015Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Combined exposures to maternal lead (Pb) and prenatal stress (PS) can act synergistically to enhance behavioral and neurochemical toxicity in offspring. Maternal Pb itself causes permanent dysfunction of the body's major stress system, the hypothalamic pituitary adrenal (HPA) axis. The current study sought to determine the potential involvement of altered negative glucocorticoid feedback as a mechanistic basis of the effects in rats of maternal Pb (0, 50 or 150 ppm in drinking water beginning 2 mo prior to breeding), prenatal stress (PS; restraint on gestational days 16-17) and combined maternal Pb+PS in 8 mo old male and female offspring. Corticosterone changes were measured over 24 h following an i.p. injection stress containing vehicle or 100 or 300 microg/kg (females) or 100 or 150 microg/kg (males) dexamethasone (DEX). Both Pb and PS prolonged the time course of corticosterone reduction following vehicle injection stress. Pb effects were non-monotonic, with a greater impact at 50 vs. 150 ppm, particularly in males, where further enhancement occurred with PS. In accord with these findings, the efficacy of DEX in suppressing corticosterone was reduced by Pb and Pb+PS in both genders, with Pb efficacy enhanced by PS in females, over the first 6 h post-administration. A marked prolongation of DEX effects was found in males. Thus, Pb, PS and Pb+PS, sometimes additively, produced hypercortisolism in both genders, followed by hypocortisolism in males, consistent with HPA axis dysfunction. These findings may provide a plausible unifying biological mechanism for the reported links between Pb exposure and stress-associated diseases and disorders mediated via the HPA axis, including obesity, hypertension, diabetes, anxiety, schizophrenia and depression. They also suggest broadening of Pb screening programs to pregnant women in high stress environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.