Who was studied, and how
Four numbers in the abstract
Where each one falls
Where it lands on the map
What it changes
Among 2 other studies
65people with type 2 diabetes, in this paper
The trial randomly assignedassigned by chance
colesevelam 3.75 g/day
placebo
Probably lowered total LDL particle concentration−242
No clear effect on small LDL-P−207
No clear effect on large LDL-P−30.0
randomisedthe abstract, start to end
… particle concentration (LDL-P) by 15.5% (-242 nmol/L [-412,-72], p=0.006) primarily due to lowering in small LDL-P (-207 nmol/L [-418,4], p=0.054) and a lesser reduction in large LDL-P [-30 nmol/L [-118,58], p=0.496) and IDL-P (-5 nmol/L [-21,11], p=0.557).
← favours treatmentfavours comparator →
could be chanceTotal LDL particle concentration (LDL-P)colesevelam 3.75 g/day vs placebo
−242−412 to −72.0
Small LDL-Pcolesevelam 3.75 g/day vs placebo
−207−418 to 4.00
Large LDL-Pcolesevelam 3.75 g/day vs placebo
−30−118 to 58.0
IDL-Pcolesevelam 3.75 g/day vs placebo
−5−21.0 to 11.0
Other lipid agentsOther glucose-loweringLipids
Other glucose-lowering × lipidshelps?mixed
unlikelylikely
0.000.00 without it
Other lipid agents × lipidshelps?mixed
unlikelylikely
0.500.50 without it
← favours treatmentfavours comparator →
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