ArticleThe Journal of physiology2009
Rate-sensitive contractile responses of lymphatic vessels to circumferential stretch.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 49 citations in OpenAlex.
- The Enigmas of Lymphatic Muscle Cells: Where Do They Come From, How Are They Maintained, and Can They Regenerate?Current rheumatology reviews · 2023Review
- Lymphatic remodelling in response to lymphatic injury in the hind limbs of sheep.Nature biomedical engineering · 2020Article
- Axial stretch regulates rat tail collecting lymphatic vessel contractions.Scientific reports · 2020Article
- Entrainment of Lymphatic Contraction to Oscillatory Flow.Scientific reports · 2019Article
- Lymphatic Vessel Network Structure and Physiology.Comprehensive Physiology · 2018Review
- Contraction of collecting lymphatics: organization of pressure-dependent rate for multiple lymphangions.Biomechanics and modeling in mechanobiology · 2018Article
- Differences in L-type CaAmerican journal of physiology. Heart and circulatory physiology · 2018Article
- Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis.Nature reviews. Rheumatology · 2018Review
- Lymphatic function measurements influenced by contrast agent volume and body position.JCI insight · 2018Article
- Lymphatic System Flows.Annual review of fluid mechanics · 2018Article
- Valve-related modes of pump failure in collecting lymphatics: numerical and experimental investigation.Biomechanics and modeling in mechanobiology · 2017Article
- Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm's Canal Reporter Rat.Scientific reports · 2017Article
- A lumped parameter model of mechanically mediated acute and long-term adaptations of contractility and geometry in lymphatics for characterization of lymphedema.Biomechanics and modeling in mechanobiology · 2016Article
- Lymphatic pumping: mechanics, mechanisms and malfunction.The Journal of physiology · 2016Review
- The Lymphatic System in Disease Processes and Cancer Progression.Annual review of biomedical engineering · 2016Review
- Consequences of intravascular lymphatic valve properties: a study of contraction timing in a multi-lymphangion model.American journal of physiology. Heart and circulatory physiology · 2016Article
- Effects of dynamic shear and transmural pressure on wall shear stress sensitivity in collecting lymphatic vessels.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Bridging the divide between pathogenesis and detection in lymphedema.Seminars in cell & developmental biology · 2015Review
- Mechanical forces and lymphatic transport.Microvascular research · 2014Review
- Ex vivo lymphatic perfusion system for independently controlling pressure gradient and transmural pressure in isolated vessels.Annals of biomedical engineering · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Phasic contractile activity in rat portal vein is more sensitive to the rate of change in length than to absolute length and this response is widely assumed to be a general characteristic of myogenic behaviour for vascular smooth muscle. Previously, we found that rat lymphatic vessels exhibit phasic contractile behaviour similar to that of portal vein. In the present study, we hypothesized that lymphatic muscle would exhibit rate-sensitive contractile responses to stretch. The hypothesis was tested on rat mesenteric lymphatics (90-220 microm, i.d.) using servo-controlled wire- and pressure-myograph systems to enable ramp increases in force or pressure at different rates. Under isometric conditions in wire-myograph preparations, both the amplitude and the frequency of phasic activity were enhanced at more optimal preloads, but superimposed upon this effect were bursts of contractions that occurred only during fast preload ramps. In such cases, the ratio of contraction frequency during the ramp to that at the subsequent plateau (at optimal preload) was > 1. Further, the frequency ratio increased as a function of the preload ramp speed, consistent with a rate-sensitive mechanism. In contrast, the amplitude ratio was < 1 and declined further with higher ramp speeds. Downward preload ramps produced corresponding rate-sensitive inhibition of contraction frequency but not amplitude. Similar findings were obtained in pressurized lymphatics in response to pressure ramps and steps. Our results suggest that lymphatics are sensitive to the rate of change in preload/pressure in a way that is different from portal vein, possibly because the pacemaker for generating electrical activity is rate sensitive but lymphatic muscle is not. The behaviour may be widely present in collecting lymphatic vessels and is probably an important mechanism for rapid adaptation of the lymphatic pump to local vascular occlusion.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.