Evidence map›Paper›PMID 19056664›Full record

ReviewThe Journal of nutrition2009

Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: mechanisms of action and implications.

Arion Kennedy, Kristina Martinez, Chia-Chi Chuang, Kathy LaPoint, Michael McIntosh

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in The Journal of nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07178145 (MRI of Epicardial Adipose Tissue Composition), which is not on this map. Cited by 218 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
218citing papers in PubMed, 9 pooled it
20.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07178145 phase4recruitingstarted 2025, after this paper: background citation

MRI of Epicardial Adipose Tissue Composition: Development of Methods and Application to Heart Failure With Preserved Ejection Fraction

Ran2025Enrolled192Registered outcomes6Posted comparisons0ConditionsEpicardial Adipose Tissue, Heart Failure Preserved Ejection FractionArmsGLP-1RA
PMID 26971994PMID 39323040PMID 18509197PMID 18777528PMID 21868182PMID 22334300PMID 22777847PMID 26527483PMID 38878970PMID 37814776PMID 37797885PMID 37325396other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

218 citing papers in PubMed, 9 syntheses or guidelines pooled it, 557 citations in OpenAlex.

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  4. The effects of dietary patterns and food groups on symptomatic osteoarthritis: A systematic review.Nutrition & dietetics : the journal of the Dietitians Association of Australia · 2023
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158 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Arion KennedyDepartment of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27402, USA.
Kristina Martinez
Chia-Chi Chuang
Kathy LaPoint
Michael McIntosh
University of North Carolina at Greensboro · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review highlights the inflammatory and insulin-antagonizing effects of saturated fatty acids (SFA), which contribute to the development of metabolic syndrome. Mechanisms responsible for these unhealthy effects of SFA include: 1) accumulation of diacylglycerol and ceramide; 2) activation of nuclear factor-kappaB, protein kinase C-, and mitogen-activated protein kinases, and subsequent induction of inflammatory genes in white adipose tissue, immune cells, and myotubes; 3) decreased PPARgamma coactivator-1 alpha/beta activation and adiponectin production, which decreases the oxidation of glucose and fatty acids (FA); and 4) recruitment of immune cells like macrophages, neutrophils, and bone marrow-derived dendritic cells to WAT and muscle. Several studies have demonstrated potential health benefits of substituting SFA with unsaturated FA, particularly oleic acid and (n-3) FA. Thus, reducing consumption of foods rich in SFA and increasing consumption of whole grains, fruits, vegetables, lean meats and poultry, fish, low-fat dairy products, and oils containing oleic acid or (n-3) FA is likely to reduce the incidence of metabolic disease.

Indexed as

Adipose TissueFatty AcidsHumansInflammationInsulin ResistanceObesityFatty Acids

Identifiers

PMID19056664
OpenAlexW2123594380

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.