ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2009
Splice variants of neuronal nitric oxide synthase are present in the rat kidney.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
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- Collecting Duct Nitric Oxide Synthase 1ß Activation Maintains Sodium Homeostasis During High Sodium Intake Through Suppression of Aldosterone and Renal Angiotensin II Pathways.Journal of the American Heart Association · 2017Article
- σ1-Receptor Agonism Protects against Renal Ischemia-Reperfusion Injury.Journal of the American Society of Nephrology : JASN · 2017Article
- Macula Densa Nitric Oxide Synthase 1β Protects against Salt-Sensitive Hypertension.Journal of the American Society of Nephrology : JASN · 2016Article
- Inhibition of Nitric Oxide Synthase 1 Induces Salt-Sensitive Hypertension in Nitric Oxide Synthase 1α Knockout and Wild-Type Mice.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Dynamin-2 is a novel NOS1β interacting protein and negative regulator in the collecting duct.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Influence of Acute High Glucose on Protein Abundance Changes in Murine Glomerular Mesangial Cells.Journal of diabetes research · 2016Article
- Detection of cervical cancer biomarker patterns in blood plasma and urine by differential scanning calorimetry and mass spectrometry.PloS one · 2014Article
- Renal nitric oxide synthase and antioxidant preservation in Cyp1a1-Ren-2 transgenic rats with inducible malignant hypertension.American journal of hypertension · 2013Article
- Renal collecting duct NOS1 maintains fluid-electrolyte homeostasis and blood pressure.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Distinct regulation of inner medullary collecting duct nitric oxide production from mice and rats.Clinical and experimental pharmacology & physiology · 2013Article
- Nitric oxide and the A and B of endothelin of sodium homeostasis.Current opinion in nephrology and hypertension · 2013Review
- Sexual dimorphism: the aging kidney, involvement of nitric oxide deficiency, and angiotensin II overactivity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Review
- Extracellular signal-regulated kinases 1/2 signaling pathways are not involved in endothelin regulation of mouse inner medullary collecting duct nitric oxide production.Life sciences · 2012Article
- Sexual dimorphism in development of kidney damage in aging Fischer-344 rats.Gender medicine · 2012Article
- Nebivolol does not protect against 5/6 ablation/infarction induced chronic kidney disease in rats - comparison with angiotensin II receptor blockade.Life sciences · 2012Article
- Protective actions of nebivolol on chronic nitric oxide synthase inhibition-induced hypertension and chronic kidney disease in the rat: a comparison with angiotensin II receptor blockade.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2012Article
- Nitric oxide synthase derangements and hypertension in kidney disease.Current opinion in nephrology and hypertension · 2012Review
- Twelve weeks of treadmill exercise does not alter age-dependent chronic kidney disease in the Fisher 344 male rat.The Journal of physiology · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDecreased renal cortical neuronal NO synthase (nNOS) abundance/activity correlates with progression of chronic kidney disease (CKD) in a number of animal models.
methodsWestern blotting with both N-terminal and C-terminal antibodies, immunoprecipitation, proteomics, RT-PCR and in situ hybridization were used to identify nNOS splice variants in the rat kidney.
resultsWe have identified two nNOS proteins and transcripts in the rat kidney; nNOSalpha (approximately 160 kDa) and nNOSbeta (approximately 140 kDa), a catalytically active exon-2 deletion variant, lacking both the PDZ and protein inhibitor of nNOS (PIN) domains. We also report that nNOSbeta protein abundance is increased in the kidney at 11 weeks following 5/6th nephrectomy (5/6NX)-induced CKD while nNOSalpha protein abundance is diminished. The transcript data parallel the protein data in 5/6NX. By in situ hybridization, there is abundant nNOSalpha mRNA widely distributed throughout the normal kidney cortex, with very sparse nNOSbeta mRNA confined to a few proximal tubules. In a second injury model (6 weeks after 5/6 renal mass reduction by combined right kidney ablation and infarction of approximately 2/3 of the left kidney; 5/6 A/I), nNOSalpha mRNA almost disappears from the kidney cortex while nNOSbeta mRNA abundance increases in tubules and tubulo-interstitium.
conclusionThe renal cortical nNOSbeta protein is present in low abundance in the normal kidney and increases with injury, in an inverse pattern of change with the nNOSalpha.
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