Statins × lipids

TrialCirculation2009

Evidence for statin pleiotropy in humans: differential effects of statins and ezetimibe on rho-associated coiled-coil containing protein kinase activity, endothelial function, and inflammation.

Ping-Yen Liu et al.PubMed ↗Full text ↗Publisher ↗

  • Simvastatin 40 mg/dlooks bad hereHigher LDL cholesterol, no range given.No ranges given.

What the trial testedas reported · 20 people · 2009

No range given

Reported higher LDL cholesterol, no range given

38×

simvastatin 40 mg/d vs placebo tablets

Bigger than almost all on the map

As reported

RR 38 %, no interval · the paper's word: low-density lipoprotein cholesterol

Who was studied, and how

20people with dyslipidemia, in this paper

The trial randomly assignedassigned by chance

simvastatin 40 mg/d
placebo tablets

Reported higher LDL cholesterol, no range given38×

randomised

the abstract, start to end

low-density lipoprotein cholesterol by 38% and C-reactive protein by 38%

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
Low-density lipoprotein cholesterolsimvastatin 40 mg/d vs placebo tablets
RR 38
StatinsLipids

Statins × lipidshelps?mixed

unlikelylikely
0.500.78 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 19075102