Statins × blood pressure

TrialCirculation2009

Impact of statin therapy on central aortic pressures and hemodynamics: principal results of the Conduit Artery Function Evaluation-Lipid-Lowering Arm (CAFE-LLA) Study.

Bryan Williams et al.PubMed ↗Publisher ↗

What the trial testedrandomised · 891 people · 2009

Randomised comparison

Probably lowered lipids

−32.4mg/dL−36.3 to −28.6

As reported

difference −32.4 mg/dL, 95% CI −36.3 to −28.6

Range includes no effect

No clear effect on blood pressure

−0.10mm Hg−1.80 to +1.60

As reported

difference −0.1 mm Hg, 95% CI −1.80 to 1.60

Range includes no effect

No clear effect on blood pressure

−0.02mm Hg−1.60 to +1.60

As reported

difference −0.02 mm Hg, 95% CI −1.60 to 1.60

Range includes no effect

No clear effect on cardiac & vascular function

−0.50mm Hg−2.30 to +1.20

As reported

difference −0.5 mm Hg, 95% CI −2.30 to 1.20

+3 more in the walkthrough ↓

Seven numbers in the abstract

the abstract, start to end

low-density lipoprotein cholesterol by 32.4 mg/dL (95% confidence interval

in brachial systolic blood pressure, -0.1 mm Hg [95% CI, -1.8 to 1.6], P=0.9; change in brachial pulse pressure, -0.02 mm Hg [95% CI, -1.6 to 1.6],

in aortic systolic blood pressure, -0.5 mm Hg [95% CI, -2.3 to 1.2], P=0.5; change in aortic pulse pressure, -0.4 mm Hg [95% CI, -1.9 to 1.0], P=0.6) and had no influence on augmentation index (change in augmentation index, -0.4%; 95% CI, -1.7 to 0.8; P=0.5) or heart rate (change in heart rate, 0.25 bpm; 95% CI, -1.3 to 1.8;

← favours treatmentfavours comparator →
could be chance
Lipids
−32.4−36.3 to −28.6
Blood pressure
−0.1−1.80 to 1.60
Blood pressure
−0.02−1.60 to 1.60
Cardiac & vascular function
−0.5−2.30 to 1.20
Blood pressure
−0.4−1.90 to 1.00
Cardiac & vascular function
−0.4−1.70 to 0.80
Cardiac & vascular function
0.25−1.30 to 1.80
StatinsLipidsBlood pressureCardiac & vascular function

Statins × blood pressurehelps?replicated

unlikelylikely
0.830.83 without it

Statins × cardiac & vascular functionhelps?mixed

unlikelylikely
0.500.50 without it

Statins × lipidshelps?mixed

unlikelylikely
0.500.50 without it
← favours treatmentfavours comparator →
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Full record →Abstract, authors, funding and every citing paper · PMID 19103995