ArticleDevelopment (Cambridge, England)2009
Fasciclin 2, the Drosophila orthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- Sequential formation ofScience advances · 2026Article
- A new paradigm considering multicellular adhesion, repulsion and attraction represent diverse cellular tile patterns.PLoS computational biology · 2025Article
- Fas2EB112: a tale of two chromosomes.G3 (Bethesda, Md.) · 2024Article
- Article
- Fasciclin 2 functions as an expression-level switch on EGFR to control organ shape and size in Drosophila.PloS one · 2024Article
- Review
- Article
- Fasciclin 2 plays multiple roles in promoting cell migration within the developing nervous system of Manduca sexta.Developmental biology · 2023Article
- Molecular and Developmental Signatures of Genital Size Macro-Evolution in Bugs.Molecular biology and evolution · 2022Article
- Fasciclin 2 engages EGFR in an auto-stimulatory loop to promote imaginal disc cell proliferation in Drosophila.PLoS genetics · 2022Article
- Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer's disease and normal physiology.Frontiers in cell and developmental biology · 2022Review
- RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion.The Journal of cell biology · 2021Article
- Neuronal immunoglobulin superfamily cell adhesion molecules in epithelial morphogenesis: insights fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Histone deacetylase (Rpd3) regulatesOpen biology · 2020Article
- Proteomics analysis of Trichoplusia ni midgut epithelial cell brush border membrane vesicles.Insect science · 2019Article
- Article
- Dynamic genome wide expression profiling of Drosophila head development reveals a novel role of Hunchback in retinal glia cell development and blood-brain barrier integrity.PLoS genetics · 2018Article
- Regulatory mechanisms of EGFR signalling during Drosophila eye development.Cellular and molecular life sciences : CMLS · 2016Review
- The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules.Nature communications · 2016Article
- C-terminal Src Kinase Gates Homeostatic Synaptic Plasticity and Regulates Fasciclin II Expression at the Drosophila Neuromuscular Junction.PLoS genetics · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Adhesion proteins not only control the degree to which cells adhere to each other but are increasingly recognised as regulators of intercellular signalling. Using genetic screening in Drosophila, we have identified Fasciclin 2 (Fas2), the Drosophila orthologue of neural cell adhesion molecule (NCAM), as a physiologically significant and specific inhibitor of epidermal growth factor receptor (EGFR) signalling in development. We find that loss of fas2 genetically interacts with multiple genetic conditions that perturb EGFR signalling. Fas2 is expressed in dynamic patterns during imaginal disc development, and in the eye we have shown that this depends on EGFR activity, implying participation in a negative-feedback loop. Loss of fas2 causes characteristic EGFR hyperactivity phenotypes in the eye, notum and wing, and also leads to downregulation of Yan, a transcriptional repressor targeted for degradation by EGFR activity. No significant genetic interactions were detected with the Notch, Wingless, Hedgehog or Dpp pathways, nor did Fas2 inhibit the FGF receptor or Torso, indicating specificity in the inhibitory role of Fas2 in EGFR signalling. Our results introduce a new regulatory interaction between an adhesion protein and a Drosophila signalling pathway and highlight the extent to which the EGFR pathway must be regulated at multiple levels.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.