Evidence map›Paper›PMID 19208729›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2009

Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses.

Karen L Teff, Joanne Grudziak, Raymond R Townsend, Tamara N Dunn, Ryan W Grant, Sean H Adams, Nancy L Keim, Bethany P Cummings, Kimber L Stanhope, Peter J Havel

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04898621 (The Effect of Dietary Fructose on Gut Microbiota and Hepatosteatosis in Healthy Men), which is not on this map. Cited by 140 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 6 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04898621 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effect of Dietary Fructose on Gut Microbiota and Hepatosteatosis in Healthy Men

TypeinterventionalSponsorShanghai Zhongshan HospitalRan2021 to 2022Enrolled58ConditionsHepatic Steatosis, Dietary Fructose ExposureArms75g fructose solution, 150g fructose solution
3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 6 syntheses or guidelines pooled it, 300 citations in OpenAlex.

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  3. Relation of total sugars, fructose and sucrose with incident type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2017
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80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Karen L TeffMonell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA. kteff@pobox.upenn.edu
Joanne Grudziak
Raymond R Townsend
Tamara N Dunn
Ryan W Grant
Sean H Adams
Nancy L Keim
Bethany P Cummings
Kimber L Stanhope
Peter J Havel
University of California, Davis · USWestern Human Nutrition Research Center · USUniversity of Pennsylvania · USMonell Chemical Senses Center · US

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI JOSHUA D RABINOWITZ · 1986 to 2026
$48.3M
ZINC GLUCONATE GLYCINE LOZENGES &VITAMIN C EFFECTS ON COMMON COLDM01RR000042 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BREWER, GEORGE J · 1985 to 2007
$40.8M
Effects of 2wk fructose & HFCS consumption on lipid dysregulation & insulin resisR01HL091333 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAVEL, PETER J · 2008 to 2012
$2.0M
Dietary Fructose: Hormones &TG/Lipoprotein MetabolismR01HL075675 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI HAVEL, PETER J · 2004 to 2008
$1.8M
Fatty acid sources of fructose and HFCS-induced postprandial hypertriglyceridemiaR01HL107256 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAVEL, PETER J, SCHWARZ, JEAN-MARC · 2011 to 2014
$1.5M
VAGAL CONTROL OF INSULIN RELEASE IN HUMANSR01DK058003 · NIDDK · MONELL CHEMICAL SENSES CENTER · PI TEFF, KAREN L · 2000 to 2003
$1.2M
Effects of Chromium on Progression of Insulin ResistanceR21AT002599 · NCCIH · UNIVERSITY OF CALIFORNIA DAVIS · PI HAVEL, PETER J · 2004 to 2006
$598k
Effects of fish oil and alpha lipoic on the progression of insulin resistanceR21AT003645 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAVEL, PETER J · 2006 to 2008
$591k
Fructose vs Glucose: Leptin, Appetite and Food IntakeR03DK058108 · NIDDK · UNIVERSITY OF CALIFORNIA DAVIS · PI HAVEL, PETER J · 2001 to 2002
$148k
NCCIH NIH HHS AT-002599NCCIH NIH HHS AT-003645NCCIH NIH HHS R21 AT002599NCCIH NIH HHS R21 AT003645NCRR NIH HHS M01 RR000042NCRR NIH HHS M01-RR00042NHLBI NIH HHS HL-075675NHLBI NIH HHS HL-091333NHLBI NIH HHS R01 HL075675NHLBI NIH HHS R01 HL091333NHLBI NIH HHS R01 HL107256NIDDK NIH HHS DK-19525NIDDK NIH HHS DK-58003NIDDK NIH HHS DK-58108NIDDK NIH HHS P30 DK019525NIDDK NIH HHS R01 DK058003NIDDK NIH HHS R03 DK058108
6 · The paper itself

Abstract

contextCompared with glucose-sweetened beverages, consumption of fructose-sweetened beverages with meals elevates postprandial plasma triglycerides and lowers 24-h insulin and leptin profiles in normal-weight women. The effects of fructose, compared with glucose, ingestion on metabolic profiles in obese subjects has not been studied.

objectiveThe objective of the study was to compare the effects of fructose- and glucose-sweetened beverages consumed with meals on hormones and metabolic substrates in obese subjects. DESIGN AND

settingThe study had a within-subject design conducted in the clinical and translational research center.

participantsParticipants included 17 obese men (n = 9) and women (n = 8), with a body mass index greater than 30 kg/m(2).

interventionsSubjects were studied under two conditions involving ingestion of mixed nutrient meals with either glucose-sweetened beverages or fructose-sweetened beverages. The beverages provided 30% of total kilocalories. Blood samples were collected over 24 h.

main outcome measuresArea under the curve (24 h AUC) for glucose, lactate, insulin, leptin, ghrelin, uric acid, triglycerides (TGs), and free fatty acids was measured.

resultsCompared with glucose-sweetened beverages, fructose consumption was associated with lower AUCs for insulin (1052.6 +/- 135.1 vs. 549.2 +/- 79.7 muU/ml per 23 h, P < 0.001) and leptin (151.9 +/- 22.7 vs. 107.0 +/- 15.0 ng/ml per 24 h, P < 0.03) and increased AUC for TG (242.3 +/- 96.8 vs. 704.3 +/- 124.4 mg/dl per 24 h, P < 0.0001). Insulin-resistant subjects exhibited larger 24-h TG profiles (P < 0.03).

conclusionsIn obese subjects, consumption of fructose-sweetened beverages with meals was associated with less insulin secretion, blunted diurnal leptin profiles, and increased postprandial TG concentrations compared with glucose consumption. Increases of TGs were augmented in obese subjects with insulin resistance, suggesting that fructose consumption may exacerbate an already adverse metabolic profile present in many obese subjects.

Indexed as

AdolescentAdultBeveragesBlood GlucoseBody Mass IndexCross-Over StudiesDietEatingFatty Acids, NonesterifiedFemaleFructoseGhrelinGlucoseHormonesHumansInsulinBlood GlucoseFatty Acids, NonesterifiedFructoseGhrelinGlucoseHormonesInsulinLeptinTriglyceridesUric Acid

Identifiers

PMID19208729
PMCPMC2684484
OpenAlexW2135266778

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.