ReviewToxicology and applied pharmacology2009
Cadmium-induced testicular injury.
Review in Toxicology and applied pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
152 citing papers in PubMed, 1 synthesis or guideline pooled it, 460 citations in OpenAlex.
- Cadmium Exposure and Testis Susceptibility: a Systematic Review in Murine Models.Biological trace element research · 2021Pooled it
- Maternal serum cadmium level during pregnancy and its association with small for gestational age infants: a population-based birth cohort study.Scientific reports · 2016Trial
- Serine Ameliorates Cadmium-Induced Testicular Injury by Regulating the PGAM1/PHGDH Signaling Pathway.Journal of biochemical and molecular toxicology · 2026Article
- Environmental estrogens and animal reproductive health: mechanisms, biomarkers, and intervention approaches.Journal of animal science and biotechnology · 2026Review
- Comprehensive sub-chronic toxicological profiling of illegal artisanal small-scale mining-polluted river bodies in four regions of Ghana.Toxicology reports · 2026Article
- Protective effect ofOpen veterinary journal · 2026Article
- Overview of Ferroptosis in Cadmium Toxicity.Biological trace element research · 2026Review
- Protective Effect of Syringic Acid Against Cadmium-Induced Testicular Toxicity in Mice.Biological trace element research · 2026Article
- Testicular organoid models in male reproductive toxicology: advances, applications, and future perspectives.Frontiers in physiology · 2026Article
- Molecular Changes Associated with Inflammation and Reproduction in Cadmium-Induced Testicular Toxicity: Mitigating Effect of Lactobacillus plantarum.Biological trace element research · 2025Article
- Endocrine Disrupting Agents: Toxicological Aspects on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Epigallocatechin-3-Gallate Enhances Antioxidant Activity and Improves Testicular and Epididymal Histology in Cadmium-Exposed Prepubertal Rats.International journal of molecular sciences · 2025Article
- Cadmium-induced disruption of exosomal secretion and cellular pathways in leydig cells.Journal of molecular histology · 2025Article
- Recent Progress inInternational journal of molecular sciences · 2025Review
- Green-synthesized silver nanoparticles from edible plant extracts ameliorate cadmium chloride-induced hepatorenal and testicular toxicity in rats.Frontiers in cell and developmental biology · 2025Article
- Revisiting cadmium-induced toxicity in the male reproductive system: an update.Archives of toxicology · 2024Review
- The Protective Role of L-Cysteine in the Regulation of Blood-Testis Barrier Functions-A Brief Review.Genes · 2024Review
- The Role of Chlorella vulgaris in Attenuating Infertility Induced by Cadmium Chloride via Suppressing Oxidative Stress and Modulating Spermatogenesis and Steroidogenesis in Male Rats.Biological trace element research · 2024Article
- Role ofAntioxidants (Basel, Switzerland) · 2024Article
- ERK/CREB and p38 MAPK/MMP14 Signaling Pathway Influences Spermatogenesis through Regulating the Expression of Junctional Proteins inInternational journal of molecular sciences · 2024Article
92 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Cadmium (Cd) is an environmental toxicant and an endocrine disruptor in humans and rodents. Several organs (e.g., kidney, liver) are affected by Cd and recent studies have illustrated that the testis is exceedingly sensitive to Cd toxicity. More important, Cd and other toxicants, such as heavy metals (e.g., lead, mercury) and estrogenic-based compounds (e.g., bisphenols) may account for the recent declining fertility in men among developed countries by reducing sperm count and testis function. In this review, we critically discuss recent data in the field that have demonstrated the Cd-induced toxicity to the testis is probably the result of interactions of a complex network of causes. This is likely to involve the disruption of the blood-testis barrier (BTB) via specific signal transduction pathways and signaling molecules, such as p38 mitogen-activated protein kinase (MAPK). We also summarize current studies on factors that confer and/or regulate the testis sensitivity to Cd, such as Cd transporters and metallothioneins, the impact of Cd on the testis as an endocrine disruptor and oxidative stress inducer, and how it may disrupt the Zn(2+) and/or Ca(2+) mediated cellular events. While much work is needed before a unified mechanistic pathway of Cd-induced testicular toxicity emerges, recent studies have helped to identify some of the likely mechanisms and/or events that take place during Cd-induced testis injury. Furthermore, some of the recent studies have shed lights on potential therapeutic or preventive approaches that can be developed in future studies by blocking or minimizing the destructive effects of Cd to testicular function in men.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.