ReviewTrends in endocrinology and metabolism: TEM2009
Insulin and JNK: optimizing metabolic homeostasis and lifespan.
Review in Trends in endocrinology and metabolism: TEM, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 72 citations in OpenAlex.
- Article
- JNK Cascade-Induced Apoptosis-A Unique Role in GqPCR Signaling.International journal of molecular sciences · 2023Review
- Immunometabolic regulation during the presence of microorganisms and parasitoids in insects.Frontiers in immunology · 2023Review
- Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and Diabetes-Related Complications.Nutrients · 2020Review
- PYCR1 interference inhibits cell growth and survival via c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathway in hepatocellular cancer.Journal of translational medicine · 2019Article
- Article
- Bidirectional regulation of osteogenic differentiation by the FOXO subfamily of Forkhead transcription factors in mammalian MSCs.Cell proliferation · 2019Review
- Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway.Frontiers in aging neuroscience · 2019Article
- The effect of noise exposure on insulin sensitivity in mice may be mediated by the JNK/IRS1 pathway.Environmental health and preventive medicine · 2018Article
- Genomic Instabilities, Cellular Senescence, and Aging:Frontiers in medicine · 2018Review
- Various Wolbachia genotypes differently influence host Drosophila dopamine metabolism and survival under heat stress conditions.BMC evolutionary biology · 2017Article
- Role of JNK during buccopharyngeal membrane perforation, the last step of embryonic mouth formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- Systemic corazonin signalling modulates stress responses and metabolism in Drosophila.Open biology · 2016Article
- Mitochondrial function in ageing: coordination with signalling and transcriptional pathways.The Journal of physiology · 2016Review
- Dissecting cellular senescence and SASP inInflammation and regeneration · 2016Review
- The drosophila T-box transcription factor midline functions within Insulin/Akt and c-Jun-N terminal kinase stress-reactive signaling pathways to regulate interommatial bristle formation and cell survival.Mechanisms of development · 2015Article
- High-fat diet induces hepatic insulin resistance and impairment of synaptic plasticity.PloS one · 2015Article
- Control of metabolic adaptation to fasting by dILP6-induced insulin signaling in Drosophila oenocytes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Mitochondrial proteostasis in the control of aging and longevity.Cell metabolism · 2014Review
- Studying aging in Drosophila.Methods (San Diego, Calif.) · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Metabolic adaptation to environmental changes is crucial for the long-term survival of an organism. Signaling mechanisms that govern this adaptation thus influence lifespan. One such mechanism is the insulin/insulin-like growth factor signaling (IIS) pathway, a central regulator of metabolism in metazoans. Recent studies have identified the stress-responsive Jun-N-terminal kinase (JNK) pathway as a regulator of IIS signaling, providing a link between environmental challenges and metabolic regulation. JNK inhibits IIS activity and, thus, promotes lifespan extension and stress tolerance. Interestingly, this interaction is also at the center of age-related metabolic diseases. Here, we review recent advances illuminating the mechanisms of the JNK-IIS interaction and its implications for metabolic diseases and lifespan in metazoans.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.