Trial reportJournal of neurology2009
Effects of statins on the progression of cerebral white matter lesion: Post hoc analysis of the ROCAS (Regression of Cerebral Artery Stenosis) study.
Trial report in Journal of neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- Therapeutic Strategies and Drug Development for Vascular Cognitive Impairment.Journal of the American Heart Association · 2017Pooled it
- Improvement in the Prediction of Cerebrovascular Events With White Matter Hyperintensity.Journal of the American Heart Association · 2023Trial
- Assessing the effectiveness of statin therapy for alleviating cerebral small vessel disease progression in people ≥75 years of age.BMC geriatrics · 2020Trial
- Analysis of Treatment Influence on Kidney Function and Brain Non-Contrast MRI Vascular Manifestations of Systemic ANCA-Associated Vasculitis with Renal Involvement.Journal of clinical medicine · 2025Article
- Mechanisms of interventions targeting modifiable factors for dementia risk reduction.Molecular neurodegeneration · 2025Review
- Dyslipidemia Treatment and Cerebrovascular Disease: Evidence Regarding the Mechanism of Stroke.Journal of lipid and atherosclerosis · 2024Review
- Leukoaraiosis: Epidemiology, Imaging, Risk Factors, and Management of Age-Related Cerebral White Matter Hyperintensities.Journal of stroke · 2024Review
- Statin use is associated with higher white matter hyperintensity volumes and lower grey matter volumes.Brain communications · 2024Article
- Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease.Molecular neurodegeneration · 2023Review
- Pragmatic evaluation of events and benefits of lipid lowering in older adults (PREVENTABLE): Trial design and rationale.Journal of the American Geriatrics Society · 2023Article
- STAREE-Mind Imaging Study: a randomised placebo-controlled trial of atorvastatin for prevention of cerebrovascular decline and neurodegeneration in older individuals.BMJ neurology open · 2023Article
- Contribution of intracranial artery stenosis to white matter hyperintensities progression in elderly Chinese patients: A 3-year retrospective longitudinal study.Frontiers in neurology · 2022Article
- ESO Guideline on covert cerebral small vessel disease.European stroke journal · 2021Article
- Rosuvastatin Improves Cognitive Function of Chronic Hypertensive Rats by Attenuating White Matter Lesions and Beta-Amyloid Deposits.BioMed research international · 2020Article
- A Comparison Study of Cilostazol and Aspirin on Changes in Volume of Cerebral Small Vessel Disease White Matter Changes: Protocol of a Multicenter, Randomized Controlled Trial.Dementia and neurocognitive disorders · 2019Article
- Subclinical Cerebrovascular Disease: Epidemiology and Treatment.Current atherosclerosis reports · 2019Review
- Asymptomatic Cerebral Small Vessel Disease: Insights from Population-Based Studies.Journal of stroke · 2019Review
- [Correlation of apolipoprotein AI, apolipoprotein B and their ratio with the severity of cerebral white matter lesions].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- Correlation analysis between the LDL-C in serum and the onset of transient ischemic attack caused by CSVD.Experimental and therapeutic medicine · 2017Article
- Stroke Caused by Atherosclerosis of the Major Intracranial Arteries.Circulation research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arteriosclerotic related cerebral white matter lesion (WML) is associated with increased risk of death, stroke, dementia, depression, gait disturbance, and urinary incontinence. We investigated the effects of statins on WML progression by performing a post hoc analysis on the ROCAS (Regression of Cerebral Artery Stenosis) study, which is a randomized, double-blind, placebo-controlled study evaluating the effects of statins upon asymptomatic middle cerebral artery stenosis progression among stroke-free individuals. Two hundreds and eight randomized subjects were assigned to either placebo (n = 102) or simvastatin 20 mg daily (n = 106) for 2 years. Baseline severity of WML was graded visually into none, mild, and severe. Volume (cm3) of WML was determined quantitatively at baseline and at end of study using a semi-automated method based on MRI. Primary outcome was the change in WML volume over 2 years. After 2 years of follow-up, there was no significant change in WML volume between the active and the placebo group as a whole. However, stratified analysis showed that for those with severe WML at baseline, the median volume increase in the active group (1.9 cm3) was less compared with that in the placebo group (3.0 cm3; P = 0.047). Linear multivariate regression analysis identified that baseline WML volume (beta = 0.63, P < 0.001) and simvastatin treatment (beta = -0.214, P = 0.043) independently predicted change in WML volume. Our findings suggest that statins may delay the progression of cerebral WML only among those who already have severe WML at baseline.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.