ArticleCellular and molecular neurobiology2009
Maternal separation induced alterations of neurogenesis in the rat rostral migratory stream.
Article in Cellular and molecular neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Effect of microwave radiation on adult neurogenesis and behavior of prenatally exposed rats.IBRO neuroscience reports · 2024Article
- Doublecortin-immunoreactive neurons in the piriform cortex are sensitive to the long lasting effects of early life stress.Frontiers in neuroscience · 2024Article
- Umbelliprenin via increase in theFrontiers in pharmacology · 2023Article
- Maternal High-Energy Diet during Pregnancy and Lactation Impairs Neurogenesis and Alters the Behavior of Adult Offspring in a Phenotype-Dependent Manner.International journal of molecular sciences · 2022Article
- Relationship between Blood Vessels and Migration of Neuroblasts in the Olfactory Neurogenic Region of the Rodent Brain.International journal of molecular sciences · 2021Review
- Effect of methotrexate on rostral migratory stream in newborn rats.The Journal of veterinary medical science · 2016Article
- Early life stress and hippocampal neurogenesis in the neonate: sexual dimorphism, long term consequences and possible mediators.Frontiers in molecular neuroscience · 2015Review
- Lithium ameliorates autistic-like behaviors induced by neonatal isolation in rats.Frontiers in behavioral neuroscience · 2014Article
- Immunohistochemical evidence for the presence of synaptic connections of nitrergic neurons in the rat rostral migratory stream.Cellular and molecular neurobiology · 2013Article
- Prenatal stress inhibits hippocampal neurogenesis but spares olfactory bulb neurogenesis.PloS one · 2013Article
- Delayed maturation and altered proliferation within the rat rostral migratory stream following maternal deprivation.European journal of histochemistry : EJH · 2011Article
- Relation among neuronal death, cell proliferation and neuronal differentiation in the gerbil main olfactory bulb after transient cerebral ischemia.Cellular and molecular neurobiology · 2010Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The aim of our study was to investigate the possibility that maternal separation, an experimental model for studies of early environmental influences, has an effect on postnatal neurogenesis in neurogenic pathway--the rostral migratory stream (RMS). 2. Rat pups were subjected to maternal separation daily for 3 h, starting from the first postnatal day (P1) till P14 or P21. In the first two groups, brains were analyzed at the age of P14 and P21, respectively. In the third group, after 3 weeks of maternal separation, 1 week of normal rearing was allowed, and the brains were analyzed at P28. The controls matched the age of maternally separated animals. Dividing cells were labeled by bromodeoxyuridine; dying cells were visualized by Fluoro-Jade C and nitric oxide (NO) producing cells by NADPH-diaphorase histochemistry. 3. Quantitative analysis of proliferating cells in the RMS showed that maternal separation decreased the number of dividing cells in all experimental groups. This decrease was most prominent in the caudal part of the RMS. The amount of dying cells was increased at the end of 3 weeks of maternal separation as well as 1 week later. The number of differentiated nitrergic cells in the RMS was increased at the end of 2 or 3 weeks of maternal separation, respectively. Besides quantitative changes, maternally separated animals showed an accelerated maturation of nitrergic cells. 4. Our results indicate that an exposure of rats to adverse environmental factors in early postnatal periods may induce acute site-specific changes in the RMS neurogenesis.
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