ArticleParticle and fibre toxicology2009
Experimental exposure to diesel exhaust increases arterial stiffness in man.
Article in Particle and fibre toxicology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Short-term Exposure to Air Pollution and Ischemic Stroke: A Systematic Review and Meta-analysis.Neurology · 2023Pooled it
- Short term exposure to air pollution and stroke: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2015Pooled it
- Lung function and self-rated symptoms in healthy volunteers after exposure to hydrotreated vegetable oil (HVO) exhaust with and without particles.Particle and fibre toxicology · 2022Trial
- Acute cardiovascular effects of controlled exposure to dilute Petrodiesel and biodiesel exhaust in healthy volunteers: a crossover study.Particle and fibre toxicology · 2021Trial
- Acute Blood Pressure and Cardiovascular Effects of Near-Roadway Exposures With and Without N95 Respirators.American journal of hypertension · 2019Trial
- Acute Effects of Electronic Cigarette Inhalation on the Vasculature and the Conducting Airways.Cardiovascular toxicology · 2019Trial
- The effects of facemasks on airway inflammation and endothelial dysfunction in healthy young adults: a double-blind, randomized, controlled crossover study.Particle and fibre toxicology · 2018Trial
- Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study.Lancet (London, England) · 2018Trial
- Effect of wood smoke exposure on vascular function and thrombus formation in healthy fire fighters.Particle and fibre toxicology · 2014Trial
- Assessment of the capacity of vehicle cabin air inlet filters to reduce diesel exhaust-induced symptoms in human volunteers.Environmental health : a global access science source · 2014Trial
- Exposure to wood smoke increases arterial stiffness and decreases heart rate variability in humans.Particle and fibre toxicology · 2013Trial
- Antioxidant airway responses following experimental exposure to wood smoke in man.Particle and fibre toxicology · 2010Trial
- Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions.Particle and fibre toxicology · 2010Trial
- Association between exposure to air pollution and arterial stiffness in participants with and without atherosclerotic cardiovascular disease.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Pulmonary and cardiovascular responses to repeated ozone exposure during exercise in adults with exercise-induced bronchoconstriction.Physiological reports · 2026Article
- Controlled human exposures: a review and comparison of the health effects of diesel exhaust and wood smoke.Particle and fibre toxicology · 2024Review
- Cross-shift changes in pulmonary function and occupational exposure to particulate matter among e-waste workers in Ghana.Frontiers in public health · 2024Article
- Article
- Air Pollution and Cerebrovascular Disorders with Special Reference to Asia: An Overview.Annals of Indian Academy of Neurology · 2022Review
- The cardiovascular effects of air pollution: Prevention and reversal by pharmacological agents.Pharmacology & therapeutics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
introductionExposure to air pollution is associated with increased cardiovascular morbidity, although the underlying mechanisms are unclear. Vascular dysfunction reduces arterial compliance and increases central arterial pressure and left ventricular after-load. We determined the effect of diesel exhaust exposure on arterial compliance using a validated non-invasive measure of arterial stiffness.
methodsIn a double-blind randomized fashion, 12 healthy volunteers were exposed to diesel exhaust (approximately 350 mug/m3) or filtered air for one hour during moderate exercise. Arterial stiffness was measured using applanation tonometry at the radial artery for pulse wave analysis (PWA), as well as at the femoral and carotid arteries for pulse wave velocity (PWV). PWA was performed 10, 20 and 30 min, and carotid-femoral PWV 40 min, post-exposure. Augmentation pressure (AP), augmentation index (AIx) and time to wave reflection (Tr) were calculated.
resultsBlood pressure, AP and AIx were generally low reflecting compliant arteries. In comparison to filtered air, diesel exhaust exposure induced an increase in AP of 2.5 mmHg (p = 0.02) and in AIx of 7.8% (p = 0.01), along with a 16 ms reduction in Tr (p = 0.03), 10 minutes post-exposure.
conclusionAcute exposure to diesel exhaust is associated with an immediate and transient increase in arterial stiffness. This may, in part, explain the increased risk for cardiovascular disease associated with air pollution exposure. If our findings are confirmed in larger cohorts of susceptible populations, this simple non-invasive method of assessing arterial stiffness may become a useful technique in measuring the impact of real world exposures to combustion derived-air pollution.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.