ArticleDiabetologia2009
Early autonomic dysfunction in type 1 diabetes: a reversible disorder?
Article in Diabetologia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 83 citations in OpenAlex.
- Oxygen-induced impairment in arterial function is corrected by slow breathing in patients with type 1 diabetes.Scientific reports · 2017Trial
- Effects of a single bout of interval hypoxia on cardiorespiratory control and blood glucose in patients with type 2 diabetes.Diabetes care · 2013Trial
- Downregulation of neuronal nitric oxide synthase (nNOS) within the paraventricular nucleus in Ins2Nitric oxide : biology and chemistry · 2025Article
- Advanced cardiovascular physiology in an individual with type 1 diabetes after 10-year ketogenic diet.American journal of physiology. Cell physiology · 2024Article
- Determinants of the heart rate variability in type 1 diabetes mellitus.Frontiers in endocrinology · 2023Article
- Normative values of resting heart rate variability in young male contact sport athletes: Reference values for the assessment and treatment of concussion.Frontiers in sports and active living · 2022Article
- Exercise and nutrition in type 1 diabetes: Insights from the FinnDiane cohort.Frontiers in endocrinology · 2022Review
- Persons with type 1 diabetes have low blood oxygen levels in the supine and standing body positions.BMJ open diabetes research & care · 2021Article
- Assessment of baroreceptor reflex sensitivity in young obese Saudi males at rest and in response to physiological challenges.Physiological reports · 2020Article
- Percussion Entropy Analysis of Synchronized ECG and PPG Signals as a Prognostic Indicator for Future Peripheral Neuropathy in Type 2 Diabetic Subjects.Diagnostics (Basel, Switzerland) · 2020Article
- Cardiac autonomic neuropathy in nonobese young adults with type 1 diabetes.Annals of pediatric endocrinology & metabolism · 2019Article
- Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: What Is Defined, What Is New, and What Is Unmet.Diabetes & metabolism journal · 2019Review
- Pulmonary Vein Ganglia Are Remodeled in the Diabetic Heart.Journal of the American Heart Association · 2018Article
- Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment.World journal of diabetes · 2018Review
- Integrated Cardio-Respiratory Control: Insight in Diabetes.Current diabetes reports · 2016Review
- Valsalva maneuver unveils central baroreflex dysfunction with altered blood pressure control in persons with a history of mild traumatic brain injury.BMC neurology · 2016Article
- Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy.World journal of diabetes · 2015Review
- Cardiovascular magnetic resonance imaging-based computational fluid dynamics/fluid-structure interaction pilot study to detect early vascular changes in pediatric patients with type 1 diabetes.Pediatric cardiology · 2015Article
- Autonomic control during acute hypoglycemia in type 1 diabetes mellitus.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2014Article
- Early diabetes treatment does not prevent sympathetic dysinnervation in the streptozotocin diabetic rat heart.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisCardiac autonomic neuropathy is associated with increased morbidity and mortality rates in patients with type 1 diabetes. The prevalence of early autonomic abnormalities is relatively high compared with the frequency of manifest clinical abnormalities. Thus, early autonomic dysfunction could to some extent be functional and might lead to an organic disease in a subgroup of patients only. If this is true, manoeuvres such as slow deep-breathing, which can improve baroreflex sensitivity (BRS) in normal but not in denervated hearts, could also modify autonomic modulation in patients with type 1 diabetes, despite autonomic dysfunction.
methodsWe compared 116 type 1 diabetic patients with 36 matched healthy control participants and 12 heart-transplanted participants with surgically denervated hearts. Autonomic function tests and spectral analysis of heart rate and blood pressure variability were performed. BRS was estimated by four methods during controlled (15 breaths per minute) and slow deep-breathing (six breaths per minute), and in supine and standing positions.
resultsConventional autonomic function tests were normal, but resting spectral variables and BRS were reduced during normal controlled breathing in patients with type 1 diabetes. However, slow deep-breathing improved BRS in patients with type 1 diabetes, but not in patients with surgically denervated hearts. Standing induced similar reductions in BRS in diabetic and control participants. CONCLUSIONS/
interpretationAlthough we found signs of increased sympathetic activity in patients with type 1 diabetes, we also observed a near normalisation of BRS with a simple functional test, indicating that early autonomic derangements are to a large extent functional and potentially correctable by appropriate interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.