Investigational compounds × glycemic control

TrialDiabetes care2009

Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: a double-blind placebo-controlled study.

Michael A Nauck et al.PubMed ↗Full text ↗Publisher ↗

  • Taspoglutide 10 mg once every 2 weekslooks good hereLower A1C, no range given.No ranges given.
  • Taspoglutide 10 mg once weeklylooks good hereLower A1C, no range given.No ranges given.
  • Taspoglutide 20 mg once weeklylooks good hereLower body weight loss, no range given.No ranges given.

What the trial testedas reported · 306 people · 2009

No range given

Reported lower A1C, no range given

−0.70percentage points

taspoglutide 10 mg once every 2 weeks vs placebo

As reported

difference −0.70 %, no interval · the paper's word: change in A1C (percent) from baseline

No range given

Reported lower A1C, no range given

−1.00

taspoglutide 10 mg once weekly vs placebo

As reported

difference −1.0, no interval · the paper's word: change in A1C (percent) from baseline

No range given

Reported lower body weight loss, no range given

−2.00

taspoglutide 20 mg once weekly vs placebo

As reported

difference −2.00, no interval

Who was studied, and how

306people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

taspoglutide 10 mg once every 2 weeks
placebo

Reported lower A1C, no range given−0.70

randomised

The trial randomly assignedassigned by chance

taspoglutide 10 mg once weekly
placebo

Reported lower A1C, no range given−1.00

randomised

the abstract, start to end

from a mean +/- SD baseline of 7.9 +/- 0.7% were observed in all taspoglutide groups compared with placebo after 8 weeks of treatment: -1.0 +/- 0.1% (5 mg once weekly),

groups and the 20 mg once every 2 weeks (-1.9 +/- 0.3 kg, P =

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
Change in A1C (percent) from baselinetaspoglutide 10 mg once every 2 weeks vs placebo
−0.70
Change in A1C (percent) from baselinetaspoglutide 10 mg once weekly vs placebo
−1.0
Body weight losstaspoglutide 20 mg once weekly vs placebo
−2.00
Investigational compoundsGlycemic controlBody weight & composition

Investigational compounds × glycemic controlhelps?replicated

unlikelylikely
0.780.76 without it

Investigational compounds × body weight & compositionhelps?settled

unlikelylikely
1.001.00 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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38 papers cite it

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this paperpooled ittrialcites it
Full record →Abstract, authors, funding and every citing paper · PMID 19366970