Trial reportAtherosclerosis2009
Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes.
Trial report in Atherosclerosis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01250275 (Effects of Canola Oil on Blood Vessel Function in Peripheral Arterial Disease), which is not on this map. Cited by 44 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Canola Oil on Blood Vessel Function in Peripheral Arterial Disease (PAD)
Who cites it
44 citing papers in PubMed, 7 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Association Between Omega-3 Fatty Acid Intake and Dyslipidemia: A Continuous Dose-Response Meta-Analysis of Randomized Controlled Trials.Journal of the American Heart Association · 2023Pooled it
- Medicinal Plants with Multiple Effects on Diabetes Mellitus and Its Complications: a Systematic Review.Current diabetes reports · 2018Pooled it
- Fish oil supplementation and insulin sensitivity: a systematic review and meta-analysis.Lipids in health and disease · 2017Pooled it
- Pooled it
- Effect of fish oil on circulating adiponectin: a systematic review and meta-analysis of randomized controlled trials.The Journal of clinical endocrinology and metabolism · 2013Pooled it
- Effect of fish oil supplementation on fasting vascular endothelial function in humans: a meta-analysis of randomized controlled trials.PloS one · 2012Pooled it
- Omega-3 polyunsaturated fatty acid and insulin sensitivity: a meta-analysis of randomized controlled trials.Clinical nutrition (Edinburgh, Scotland) · 2011Pooled it
- Higher-Dose DHA Supplementation Modulates Immune Responses in Pregnancy and Is Associated with Decreased Preterm Birth.Nutrients · 2021Trial
- Assessment of DHA on reducing early preterm birth: the ADORE randomized controlled trial protocol.BMC pregnancy and childbirth · 2017Trial
- A calorie-restriction diet supplemented with fish oil and high-protein powder is associated with reduced severity of metabolic syndrome in obese women.European journal of clinical nutrition · 2015Trial
- The effects of n-3 long-chain polyunsaturated fatty acid supplementation on biomarkers of kidney injury in adults with diabetes: results of the GO-FISH trial.Diabetes care · 2013Trial
- Glu298Asp polymorphism influences the beneficial effects of fish oil fatty acids on postprandial vascular function.Journal of lipid research · 2012Trial
- Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome.The Journal of clinical endocrinology and metabolism · 2011Trial
- Systematic review of mediterranean diet interventions in menopausal women.AIMS public health · 2024Review
- Fish oil users of Greece: Predictors, knowledge and habits regarding dietary supplement use.AIMS public health · 2023Article
- Omega-3 Fatty Acids and Their Interaction with the Gut Microbiome in the Prevention and Amelioration of Type-2 Diabetes.Nutrients · 2022Review
- Clinical significance of polyunsaturated fatty acids in the prevention of cardiovascular diseases.Frontiers in nutrition · 2022Review
- Adiponectin: Structure, Physiological Functions, Role in Diseases, and Effects of Nutrition.Nutrients · 2021Review
- Randomization to Omega-3 Fatty Acid Supplementation and Endothelial Function in COPD: The COD-Fish Randomized Controlled Trial.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2021Article
- Position Statement on Fat Consumption and Cardiovascular Health - 2021.Arquivos brasileiros de cardiologia · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveOffspring of patients with type 2 diabetes (OPDs) exhibits endothelial dysfunction (ED) associated with a chronic inflammatory state. N-3 polyunsaturated fatty acids (n-3 PUFA) may have antioxidant and anti-inflammatory properties that are beneficial for cardiovascular and metabolic health. Therefore, in the present study, we tested the hypothesis that dietary supplementation with fish oil rich in n-3 PUFA may improve ED in otherwise healthy OPDs. METHODS AND
designA double-blind, placebo-controlled trial was conducted with 50 OPDs. Participants were randomized to treatment with either placebo or n-3 PUFA (2g/day) for 12 weeks. Before and after treatment we evaluated endothelial function (using flow-mediated dilation (FMD) of the brachial artery), circulating inflammatory markers (adiponectin, TNF-alpha, and high sensitivity-CRP), and insulin resistance (QUICKI).
resultsNo significant changes were observed in study outcomes in subjects treated with placebo. By contrast, when compared with baseline values, subjects treated with n-3 PUFA had significant improvement in FMD (9.1+/-5.8% vs. 11.7+/-4.4%, p=0.02) that was accompanied by decreased plasma triglycerides (117+/-73mg/dl vs. 86+/-44mg/dl, p=0.001) and TNF-alpha levels (8.9+/-2.3pg/ml vs. 6.8+/-2.7pg/ml, p=0.001), and a trend towards increased plasma adiponectin levels (7.8+/-4.5microg/ml vs. 9.5+/-5.1microg/ml, p=0.09). When data were analyzed by multiple regression analysis, decreased TNF-alpha after treatment with n-3 PUFA predicted increased FMD.
conclusionDietary supplementation with n-3 PUFA significantly improved endothelial function and reduced pro-inflammatory markers in OPDs. Thus, fish oil consumption may have beneficial cardiovascular and metabolic health effects in otherwise healthy subjects predisposed to diabetes and its vascular complications.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.