ArticleGenetics2009
A screen for modifiers of notch signaling uncovers Amun, a protein with a critical role in sensory organ development.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Autoinhibitory feedback preserves intestinal stem cell maintenance and fate commitment.The EMBO journal · 2026Article
- Developmental stage dominates cell-type identity and reveals a chromatin regulatory function for Rad50 in Drosophila.Nucleic acids research · 2026Article
- Quantifying bristle cell organization inbioRxiv : the preprint server for biology · 2025Article
- Single-nucleus transcriptomics of wing sexual dimorphism and scale cell specialization in sulphur butterflies.PLoS biology · 2025Article
- A modifier in the 129S2/SvPasCrl genome is responsible for the viability of Notch1[12f/12f] mice.BMC developmental biology · 2019Article
- TheDisease models & mechanisms · 2018Article
- Integration of Drosophila and Human Genetics to Understand Notch Signaling Related Diseases.Advances in experimental medicine and biology · 2018Review
- Discovery of progenitor cell signatures by time-series synexpression analysis during Drosophila embryonic cell immortalization.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The Notch-mediated hyperplasia circuitry in Drosophila reveals a Src-JNK signaling axis.eLife · 2015Article
- BCAS2 Regulates Delta-Notch Signaling Activity through Delta Pre-mRNA Splicing in Drosophila Wing Development.PloS one · 2015Article
- Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot.The EMBO journal · 2014Article
- A genetic strategy to measure circulating Drosophila insulin reveals genes regulating insulin production and secretion.PLoS genetics · 2014Article
- Stochastic simulation of notch signaling reveals novel factors that mediate the differentiation of neural stem cells.Journal of computational biology : a journal of computational molecular cell biology · 2014Article
- Tools and methods for studying Notch signaling in Drosophila melanogaster.Methods (San Diego, Calif.) · 2014Article
- A targeted genetic modifier screen links the SWI2/SNF2 protein domino to growth and autophagy genes in Drosophila melanogaster.G3 (Bethesda, Md.) · 2013Article
- Multiparametric analysis of CLASP-interacting protein functions during interphase microtubule dynamics.Molecular and cellular biology · 2013Article
- The Notch signalling system: recent insights into the complexity of a conserved pathway.Nature reviews. Genetics · 2012Review
- Drosophila lilliputian is required for proneural gene expression in retinal development.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster.PloS one · 2012Article
- Intracellular trafficking in Drosophila visual system development: a basis for pattern formation through simple mechanisms.Developmental neurobiology · 2011Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Notch signaling is an evolutionarily conserved pathway essential for many cell fate specification events during metazoan development. We conducted a large-scale transposon-based screen in the developing Drosophila eye to identify genes involved in Notch signaling. We screened 10,447 transposon lines from the Exelixis collection for modifiers of cell fate alterations caused by overexpression of the Notch ligand Delta and identified 170 distinct modifier lines that may affect up to 274 genes. These include genes known to function in Notch signaling, as well as a large group of characterized and uncharacterized genes that have not been implicated in Notch pathway function. We further analyze a gene that we have named Amun and show that it encodes a protein that localizes to the nucleus and contains a putative DNA glycosylase domain. Genetic and molecular analyses of Amun show that altered levels of Amun function interfere with cell fate specification during eye and sensory organ development. Overexpression of Amun decreases expression of the proneural transcription factor Achaete, and sensory organ loss caused by Amun overexpression can be rescued by coexpression of Achaete. Taken together, our data suggest that Amun acts as a transcriptional regulator that can affect cell fate specification by controlling Achaete levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.