ArticleThe Journal of physiology2009
Distinct effects of subcellular glycogen localization on tetanic relaxation time and endurance in mechanically skinned rat skeletal muscle fibres.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Ergogenic Effects of Acute Carbohydrate Feeding on Resistance Exercise Performance: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Isoenergetic Pre-Exercise Meals Varying in Carbohydrate Similarly Affect Resistance Training Volume Performance Compared to Placebo: A Crossover Trial.European journal of sport science · 2025Trial
- Local depletion of glycogen with supramaximal exercise in human skeletal muscle fibres.The Journal of physiology · 2017Trial
- Human skeletal muscle glycogen utilization in exhaustive exercise: role of subcellular localization and fibre type.The Journal of physiology · 2011Trial
- Role of glycogen availability in sarcoplasmic reticulum Ca2+ kinetics in human skeletal muscle.The Journal of physiology · 2011Trial
- Prolonged running reduces speed at the moderate-to-heavy intensity transition without additional reductions due to increased eccentric load.European journal of applied physiology · 2025Article
- Carbohydrate ingestion during prolonged exercise blunts the reduction in power output at the moderate-to-heavy intensity transition.European journal of applied physiology · 2025Article
- Exercise- and diet-induced glycogen depletion impairs performance during one-legged constant-load, high-intensity exercise in humans.Frontiers in physiology · 2025Article
- Glucose and glycogen affects CaPhysiological reports · 2024Article
- Effect of Low vs. High Carbohydrate Intake after Glycogen-Depleting Workout on Subsequent 1500 m Run Performance in High-Level Runners.Nutrients · 2024Article
- Durability of the moderate-to-heavy-intensity transition is related to the effects of prolonged exercise on severe-intensity performance.European journal of applied physiology · 2024Article
- Exercise and fatigue: integrating the role of KEuropean journal of applied physiology · 2023Review
- Fluoride as a Potential Repressor of Glycogen Metabolism in Skeletal Muscle Cell Line CCL136.Molecules (Basel, Switzerland) · 2023Article
- The molecular athlete: exercise physiology from mechanisms to medals.Physiological reviews · 2023Review
- Insulin signaling in skeletal muscle during inflammation and/or immobilisation.Intensive care medicine experimental · 2023Article
- Fibre type- and localisation-specific muscle glycogen utilisation during repeated high-intensity intermittent exercise.The Journal of physiology · 2022Article
- Specific ATPases drive compartmentalized glycogen utilization in rat skeletal muscle.The Journal of general physiology · 2022Article
- The spatial distribution of glycogen and glycogen consumption in muscle cells.The Journal of general physiology · 2022Article
- A century of exercise physiology: key concepts in regulation of glycogen metabolism in skeletal muscle.European journal of applied physiology · 2022Review
- Muscle Glycogen Metabolism and High-Intensity Exercise Performance: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2021Review
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vitro experiments indicate a non-metabolic role of muscle glycogen in contracting skeletal muscles. Since the sequence of events in excitation\#8211;contraction (E\#8211;C) coupling is known to be located close to glycogen granules, at specific sites on the fibre, we hypothesized that the distinct compartments of glycogen have specific effects on muscle fibre contractility and fatigability. Single skeletal muscle fibres (n = 19) from fed and fasted rats were mechanically skinned and divided into two segments. In one segment glycogen localization and volume fraction were estimated by transmission electron microscopy. The other segment was mechanically skinned and, in the presence of high and constant myoplasmic ATP and PCr, electrically stimulated (10 Hz, 0.8 s every 3 s) eliciting repeated tetanic contractions until the force response was decreased by 50% (mean +/- S.E.M., 81 +/- 16, range 22-252 contractions). Initially the total myofibrillar glycogen volume percentage was 0.46 +/- 0.07%, with 72 +/- 3% in the intermyofibrillar space and 28 +/- 3% in the intramyofibrillar space. The intramyofibrillar glycogen content was positively correlated with the fatigue resistance capacity (r(2) = 0.32, P = 0.02). Intermyofibrillar glycogen was inversely correlated with the half-relaxation time in the unfatigued tetanus (r(2) = 0.25, P = 0.03). These results demonstrate for the first time that two distinct subcellular populations of glycogen have different roles in contracting single muscle fibres under conditions of high myoplasmic ATP.
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