Trial reportDiabetes care2009
Obesity blunts microvascular recruitment in human forearm muscle after a mixed meal.
Trial report in Diabetes care, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome
The Impact of Fitness on Vascular Dysfunction in Adolescents With Type 1 Diabetes
The Effect of Type 1 Diabetes on Pan-Arterial Vascular Function and Insulin Sensitivity in Humans
The Impact of Fitness and Mineralocorticoid Receptor Blockade on Vascular Dysfunction in Adults With Type 1 Diabetes
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.
- Utility of Contrast-Enhanced Ultrasound for the Assessment of Skeletal Muscle Perfusion in Diabetes Mellitus: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2019Pooled it
- Role of skeletal muscle perfusion and insulin resistance in the effect of dietary sodium on heart function in overweight.ESC heart failure · 2021Trial
- Insulin-mediated muscle microvascular perfusion and its phenotypic predictors in humans.Scientific reports · 2021 · on this mapTrial
- Differential effects of nebivolol vs. metoprolol on microvascular function in hypertensive humans.American journal of physiology. Heart and circulatory physiology · 2016Trial
- Improving Peripheral and Central Vascular Adjustments during Exercise through a Training Program in Adolescents with Obesity.Obesity facts · 2016Trial
- Trial
- Early microvascular recruitment modulates subsequent insulin-mediated skeletal muscle glucose metabolism during lipid infusion.Diabetes care · 2013 · on this mapTrial
- Lipid-induced insulin resistance is not mediated by impaired transcapillary transport of insulin and glucose in humans.Diabetes · 2012Trial
- Contrast enhanced ultrasound and laser doppler flowmetry capture distinct aspects of tissue microvascular perfusion in nonhuman primates.Physiological reports · 2026Article
- Unraveling Skeletal Muscle Insulin Resistance: Molecular Mechanisms and the Restorative Role of Exercise.Circulation research · 2025Review
- Controlled induction of type 2 diabetes in mice using high fat diet and osmotic-mini pump infused streptozotocin.Scientific reports · 2025Article
- Increased adiposity is associated with altered skeletal muscle energetics.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Hemodynamics and Arterial Stiffness in Response to Oral Glucose Loading in Individuals with Type II Diabetes and Controlled Hypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2023Article
- Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance?Nutrition & diabetes · 2022Review
- Oral and intravenous glucose administration elicit opposing microvascular blood flow responses in skeletal muscle of healthy people: role of incretins.The Journal of physiology · 2022Article
- Impaired postprandial skeletal muscle vascular responses to a mixed meal challenge in normoglycaemic people with a parent with type 2 diabetes.Diabetologia · 2022Article
- Exercise-A Panacea of Metabolic Dysregulation in Cancer: Physiological and Molecular Insights.International journal of molecular sciences · 2021Review
- Association Between Obesity and Microvascular Diseases in Patients With Type 2 Diabetes Mellitus.Frontiers in endocrinology · 2021Article
- Endothelial dysfunction due to selective insulin resistance in vascular endothelium: insights from mechanistic modeling.American journal of physiology. Endocrinology and metabolism · 2020 · on this mapArticle
- Super-Resolution Ultrasound Imaging of Skeletal Muscle Microvascular Dysfunction in an Animal Model of Type 2 Diabetes.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveIngestion of a mixed meal recruits flow to muscle capillaries and increases total forearm blood flow in healthy young lean people. We examined whether these vascular responses are blunted by obesity. RESEARCH DESIGN AND
methodsWe fed eight middle-aged lean and eight obese overnight-fasted volunteers a liquid mixed meal (480 kcal). Plasma glucose and insulin were measured every 30 min, and brachial artery flow and muscle microvascular recruitment (contrast ultrasound) were assessed every 60 min over 2 h after the meal.
resultsBy 30 min, plasma glucose rose in both the lean (5.1 +/- 0.1 vs. 6.7 +/- 0.4 mmol/l, P < 0.05) and the obese groups (5.4 +/- 0.2 vs. 6.7 +/- 0.4 mmol/l, P < 0.05). Plasma insulin rose (28 +/- 4 vs. 241 +/- 30 pmol/l, P < 0.05) by 30 min in the lean group and remained elevated for 2 h. The obese group had higher fasting plasma insulin levels (65 +/- 8 pmol/l, P < 0.001) and a greater postmeal area under the insulin-time curve (P < 0.05). Brachial artery flow was increased at 120 min after the meal in the lean group (38 +/- 6 vs. 83 +/- 16 ml/min, P < 0.05) but not in the obese group. Muscle microvascular blood volume rose by 120 min in the lean group (14.4 +/- 2.2 vs. 24.4 +/- 4.2 units, P < 0.05) but not in the obese group.
conclusionsA mixed meal recruits muscle microvasculature in lean subjects, and this effect is blunted by obesity. This impaired vascular recruitment lessens the endothelial surface available and may thereby impair postprandial glucose disposal.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.