Evidence map›Paper›PMID 19494176›Full record

Trial reportAmerican journal of physiology. Regulatory, integrative and comparative physiology2009

Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome.

Elisabet Stener-Victorin, Elizabeth Jedel, Per Olof Janson, Yrsa Bergmann Sverrisdottir

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in American journal of physiology. Regulatory, integrative and comparative physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02491333 (The Effect of Acupuncture on Insulin Sensitivity of Women With Polycystic Ovary Syndrome and Insulin Resistance), which is not on this map. Cited by 76 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 16 pooled it
28.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02491333 phase3completedstarted 2015, after this paper: background citation

The Effect of Acupuncture on Insulin Sensitivity of Women With Polycystic Ovary Syndrome and Insulin Resistance: a Randomized Controlled Trial

Ran2015Enrolled342Registered outcomes12Posted comparisons0ConditionsInsulin Resistance, Polycystic Ovary SyndromeArmsMetformin, placebo metformin, sham acupuncture, true acupuncture
PMID 21950959PMID 18364705PMID 12243370PMID 11602624PMID 9165656PMID 21121941PMID 22878886PMID 21701996PMID 21672000PMID 21298999PMID 21281021PMID 20590731other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 16 syntheses or guidelines pooled it, 185 citations in OpenAlex.

  1. Pooled it
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  7. Effects of physical activity in women with polycystic ovary syndrome: a systematic review and meta-analysis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025
    Pooled it
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  12. Lifestyle changes in women with polycystic ovary syndrome.The Cochrane database of systematic reviews · 2019
    Pooled it
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  16. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline.The Journal of clinical endocrinology and metabolism · 2013 · on this map
    Guideline
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Elisabet Stener-VictorinInstitute of Neuroscience and Physiology, Dept. of Physiology, Sahlgrenska Academy, Univ. of Gothenburg, Box 434, SE-405 30 Göteborg, Sweden. elisabet.stener-victorin@neuro.gu.se
Elizabeth Jedel
Per Olof Janson
Yrsa Bergmann Sverrisdottir
University of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have recently shown that polycystic ovary syndrome (PCOS) is associated with high muscle sympathetic nerve activity (MSNA). Animal studies support the concept that low-frequency electroacupuncture (EA) and physical exercise, via stimulation of ergoreceptors and somatic afferents in the muscles, may modulate the activity of the sympathetic nervous system. The aim of the present study was to investigate the effect of these interventions on sympathetic nerve activity in women with PCOS. In a randomized controlled trial, 20 women with PCOS were randomly allocated to one of three groups: low-frequency EA (n = 9), physical exercise (n = 5), or untreated control (n = 6) during 16 wk. Direct recordings of multiunit efferent postganglionic MSNA in a muscle fascicle of the peroneal nerve before and following 16 wk of treatment. Biometric, hemodynamic, endocrine, and metabolic parameters were measured. Low-frequency EA (P = 0.036) and physical exercise (P = 0.030) decreased MSNA burst frequency compared with the untreated control group. The low-frequency EA group reduced sagittal diameter (P = 0.001), while the physical exercise group reduced body weight (P = 0.004) and body mass index (P = 0.004) compared with the untreated control group. Sagittal diameter was related to MSNA burst frequency (Rs = 0.58, P < 0.005) in the EA group. No correlation was found for body mass index and MSNA in the exercise group. There were no differences between the groups in hemodynamic, endocrine, and metabolic variables. For the first time we demonstrate that low-frequency EA and physical exercise lowers high sympathetic nerve activity in women with PCOS. Thus, treatment with low-frequency EA or physical exercise with the aim to reduce MSNA may be of importance for women with PCOS.

Indexed as

Action PotentialsAdultAmenorrheaBody Mass IndexBody WeightBody Weights and MeasuresElectroacupunctureExerciseFemaleHumansMuscle, SmoothOligomenorrheaPeroneal NervePolycystic Ovary SyndromeSympathetic Nervous SystemTestosteroneTestosterone

Identifiers

PMID19494176
OpenAlexW1977287851

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.