ArticleMetabolism: clinical and experimental2009
The influence of sex, body composition, and nonesterified fatty acids on serum adipokine concentrations.
Article in Metabolism: clinical and experimental, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The link between obesity and migraine in childhood: a systematic review.Italian journal of pediatrics · 2017Pooled it
- Adipokines and Migraine: A Systematic Review.Headache · 2016Pooled it
- Baseline Testosterone Predicts Body Composition and Metabolic Response to Testosterone Therapy.Frontiers in endocrinology · 2022Trial
- Circulating organokines in coronary artery disease and metabolic syndrome: FABP4, adiponectin, irisin, FSTL1.Biomolecules & biomedicine · 2025Article
- Sex-specific association between body mass index and cerebral microbleed progression in adults aged 50-85 years.Frontiers in neurology · 2025Article
- Clinical and Therapeutic Implications of Male Obesity.Journal of clinical medicine · 2023Review
- Role of adiponectin and free fatty acids on the association between abdominal visceral fat and insulin resistance.Cardiovascular diabetology · 2015Article
- The activities of lysyl hydroxylase 3 (LH3) regulate the amount and oligomerization status of adiponectin.PloS one · 2012Article
- Fasting insulin reflects heterogeneous physiological processes: role of insulin clearance.American journal of physiology. Endocrinology and metabolism · 2011Article
- Adiponectin expression and metabolic markers in obesity and Type 2 diabetes.Journal of endocrinological investigation · 2011Article
- Effect of weight loss on adipokine levels in obese patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2011Article
- Fatty acids from very low-density lipoprotein lipolysis products induce lipid droplet accumulation in human monocytes.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Identification and treatment of metabolic complications in pediatric obesity.Reviews in endocrine & metabolic disorders · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Serum adiponectin concentrations are higher in women than men. The sexual dimorphism for adiponectin has been attributed to the direct effects of testosterone on adipose tissue adiponectin secretion. However, serum testosterone and adiponectin concentrations are generally lower in obese men than lean men, suggesting that sex steroids may not be the only factor that contributes to sex differences in serum adiponectin. The primary objective of this study was to examine the influence of sex, body composition, and nonesterified fatty acids (NEFAs) on serum adiponectin concentrations. Women and men between the ages of 18 and 35 years were consecutively accrued into the study. Sixty-one participants were partitioned into normal-weight (15 female and 16 male) or obese (14 female and 16 male) groups. Blood samples were obtained after a 12-hour fast. Differences between groups were determined by analysis of variance with Tukey-Kramer post hoc testing. Serum adiponectin was 26% higher in women compared with men. Body mass index was associated with total serum adiponectin in men (r = -0.63, P < .05) but not women. Adiponectin was correlated with the homeostasis model assessment index in women (r = -0.56, P < .05) and men (r = -0.58, P < .05) and with NEFAs (r = -0.68, P < .05) in men only. After partitioning men and women into normal-weight and obese groups, serum adiponectin was lower and NEFAs were higher in obese men only. Homeostasis model assessment was similar between obese women and men despite higher NEFAs in the obese men. Leptin and plasminogen activator inhibitor-1 were higher in obese participants but were not associated with serum NEFAs. These results suggest that serum NEFAs may reduce adiponectin concentrations independent of their effects on insulin sensitivity in obese young men.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.