ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Analysis of Rex1 (zfp42) function in embryonic stem cell differentiation.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
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- Modeling combinatorial regulation from single-cell multi-omics provides regulatory units underpinning cell type landscape using cRegulon.Genome biology · 2025Article
- The self-renewal function of Oct-4 can be replaced by the EWS-Oct-4 fusion protein in embryonic stem cells.Cellular and molecular life sciences : CMLS · 2025Article
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- Zfp296 knockout enhances chromatin accessibility and induces a unique state of pluripotency in embryonic stem cells.Communications biology · 2023Article
- Impact of Adipose Tissue Depot Harvesting Site on the Multilineage Induction Capacity of Male Rat Adipose-Derived Mesenchymal Stem Cells: An In Vitro Study.International journal of molecular sciences · 2023Article
- Population structure, genetic diversity and prolificacy in pishan red sheep under an extreme desert environment.Frontiers in genetics · 2023Article
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- Eutherian-Specific Gene TRIML2 Attenuates Inflammation in the Evolution of Placentation.Molecular biology and evolution · 2020Article
- Cancer Stem Cells or Tumor Survival Cells?Stem cells and development · 2018Article
- Pediatric Germ Cell Tumors: A Developmental Perspective.Advances in urology · 2018Review
- Graphene Oxide-Silver Nanoparticles Nanocomposite Stimulates Differentiation in Human Neuroblastoma Cancer Cells (SH-SY5Y).International journal of molecular sciences · 2017Article
- Reduction of pluripotent gene expression in murine embryonic stem cells exposed to mechanical loading or Cyclo RGD peptide.BMC cell biology · 2017Article
- Pluripotency Factors on Their Lineage Move.Stem cells international · 2016Review
- A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics.eLife · 2015Article
- Cell Cycle-Driven Heterogeneity: On the Road to Demystifying the Transitions between "Poised" and "Restricted" Pluripotent Cell States.Stem cells international · 2015Review
- Stress-induced enzyme activation primes murine embryonic stem cells to differentiate toward the first extraembryonic lineage.Stem cells and development · 2014Article
- Zfp322a Regulates mouse ES cell pluripotency and enhances reprogramming efficiency.PLoS genetics · 2014Article
- Identification and characterization of germ cell genes expressed in the F9 testicular teratoma stem cell line.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Rex1 (zfp42) is a zinc finger protein expressed primarily in undifferentiated stem cells, both in the embryo and the adult. Upon all-trans retinoic acid induced differentiation of murine embryonic stem (ES) cells, Rex1 mRNA levels decrease several fold. To characterize the function(s) of Rex1 more extensively, we generated Rex1 double knockout ES cell lines. The disruption of the Rex1 gene enhanced the expression of ectoderm, mesoderm, and endoderm markers as compared to wild-type (Wt) cells. We propose that Rex1 acts to reduce retinoic acid induced differentiation in ES cells. We performed microarray analyses on Wt and Rex1-/- cells cultured in the presence or absence of LIF to identify potential Rex1 targets. We also evaluated gene expression in a Wt line that overexpresses Rex1 and in a Rex1-/- line in which Rex1 expression was restored. These data, taken together, suggest that Rex1 influences differentiation, cell cycle regulation, and cancer progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.