Evidence map›Paper›PMID 19633729›Full record

ArticleInternational review of research in mental retardation2008

Alzheimer's Disease in Adults with Down Syndrome.

Warren B Zigman, Darlynne A Devenny, Sharon J Krinsky-McHale, Edmund C Jenkins, Tiina K Urv, Jerzy Wegiel, Nicole Schupf, Wayne Silverman

Abstract read
In one paragraph

Article in International review of research in mental retardation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Factors Associated With Alzheimer's Dementia Diagnosis and Survival in Down Syndrome.Journal of intellectual disability research : JIDR · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. What Can We Learn About Alzheimer's Disease from People with Down Syndrome?Current topics in behavioral neurosciences · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Role of tau deposition in early cognitive decline in Down syndrome.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Warren B ZigmanDepartment of Psychology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314.
Darlynne A Devenny
Sharon J Krinsky-McHale
Edmund C Jenkins
Tiina K Urv
Jerzy Wegiel
Nicole Schupf
Wayne Silverman

Funding

Vulnerability to Alzheimers Disease in Down SyndromeP01HD035897 · NICHD · NEW YORK STATE OFFICE OF MENTAL HEALTH · PI JENKINS, EDMUND C · 1998 to 2014
$19.2M
Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI FATEMI, S. ALI, SCHLAGGAR, BRADLEY L · 2014 to 2019
$7.9M
EPIDEMIOLOGY OF MENOPAUSE AND DEMENTIA IN DOWN SYNDROMER01AG014673 · NIA · INSTITUTE FOR BASIC RES IN DEV DISABIL · PI SCHUPF, NICOLE · 1998 to 2009
$4.2M
The role of Mnbk in DS brain development and agingR01HD043960 · NICHD · INSTITUTE FOR BASIC RES IN DEV DISABIL · PI WEGIEL, JERZY · 2004 to 2008
$2.6M
GENETICS, MORTALITY AND DEMENTIA IN DOWN SYNDROMER01HD037425 · NICHD · INSTITUTE FOR BASIC RES IN DEV DISABIL · PI ZIGMAN, WARREN B · 1999 to 2003
$1.1M
NIA NIH HHS R01 AG014673NICHD NIH HHS P01 HD035897NICHD NIH HHS R01 HD037425NICHD NIH HHS R01 HD043960NICHD NIH HHS U54 HD079123
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID19633729
PMCPMC2714652

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.