Bad news for beta-cell apoptosis.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

9 citing papers in PubMed.

1. Gene Expression Profiling of Apoptotic Proteins in Circulating Peripheral Blood Mononuclear Cells in Type II Diabetes Mellitus and Modulation by Metformin.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021
   Article
2. Emerging Role of PACAP as a New Potential Therapeutic Target in Major Diabetes Complications.International journal of endocrinology · 2015
   Review
3. Tumor necrosis factor-related apoptosis-inducing ligand mediates the resolution of allergic airway inflammation induced by chronic allergen inhalation.Mucosal immunology · 2014
   Article
4. Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection.Proceedings of the National Academy of Sciences of the United States of America · 2014
   Article
5. 14-3-3 proteins are essential signalling hubs for beta cell survival.Diabetologia · 2013
   Article
6. cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets.Diabetologia · 2012
   Article
7. Trophic effects of PACAP on pancreatic islets: a mini-review.Journal of molecular neuroscience : MN · 2011
   Review
8. Mechanisms of non-apoptotic programmed cell death in diabetes and heart failure.Cell cycle (Georgetown, Tex.) · 2010
   Review
9. Blockade of interleukin 1 in type 1 diabetes mellitus.Nature reviews. Endocrinology · 2010
   Review

Corrections and comments

• Comment on
  Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells.2009

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as