Evidence map›Paper›PMID 19649766›Full record

ReviewCellular and molecular life sciences : CMLS2009

Retroelements and their impact on genome evolution and functioning.

Elena Gogvadze, Anton Buzdin

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04273061 (Canadian Atezolizumab Precision Targeting for Immunotherapy Intervention), which is not on this map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04273061 phase2recruitingnot on this mapstarted 2020, after this paper: background citation

Canadian Atezolizumab Precision Targeting for Immunotherapy Intervention

TypeinterventionalSponsorBritish Columbia Cancer AgencyRan2020 to 2027Enrolled200ConditionsBreast Cancer, Lung Cancer, Gastrointestinal Cancer, Genitourinary CancerArmsAtezolizumab
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 144 citations in OpenAlex.

  1. Article
  2. Chromosome-contiguous nuclear genome ofOne health (Amsterdam, Netherlands) · 2025
    Article
  3. Chromosome-ContiguousInternational journal of molecular sciences · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Aryl Hydrocarbon Receptor: From Homeostasis to Tumor Progression.Frontiers in cell and developmental biology · 2022
    Review
  13. Article
  14. Viruses Defined by the Position of the Virosphere within the Replicator Space.Microbiology and molecular biology reviews : MMBR · 2021
    Article
  15. Article
  16. Aux/IAA14 Regulates microRNA-Mediated Cold Stress Response inInternational journal of molecular sciences · 2020
    Article
  17. Review
  18. Article
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Elena GogvadzeShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya st, 117997 Moscow, Russia. e.gogvadze@gmail.com
Anton Buzdin
Institute of Bioorganic Chemistry · RUInstitute of Bioorganic Chemistry · BY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retroelements comprise a considerable fraction of eukaryotic genomes. Since their initial discovery by Barbara McClintock in maize DNA, retroelements have been found in genomes of almost all organisms. First considered as a "junk DNA" or genomic parasites, they were shown to influence genome functioning and to promote genetic innovations. For this reason, they were suggested as an important creative force in the genome evolution and adaptation of an organism to altered environmental conditions. In this review, we summarize the up-to-date knowledge of different ways of retroelement involvement in structural and functional evolution of genes and genomes, as well as the mechanisms generated by cells to control their retrotransposition.

Indexed as

Evolution, MolecularGenomeModels, GeneticEukaryotaGene Expression RegulationLong Interspersed Nucleotide ElementsPolyadenylationPseudogenesRecombination, GeneticRetroelementsRNA Splice SitesShort Interspersed Nucleotide ElementsTransduction, GeneticRetroelementsRNA Splice Sites

Identifiers

PMID19649766
PMCPMC11115525
OpenAlexW2008518693

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.