Evidence map›Paper›PMID 19651918›Full record

Trial reportDiabetes care2009

Regulatory effects of fenofibrate and atorvastatin on lipoprotein A-I and lipoprotein A-I:A-II kinetics in the metabolic syndrome.

Dick C Chan, Gerald F Watts, Esther M M Ooi, Kerry-Anne Rye, Juying Ji, Anthony G Johnson, P Hugh R Barrett

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Dick C ChanMetabolic Research Centre, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.
Gerald F Watts
Esther M M Ooi
Kerry-Anne Rye
Juying Ji
Anthony G Johnson
P Hugh R Barrett
University of Western Australia · AUBristol-Myers Squibb (United States) · USUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSubjects with the metabolic syndrome have reduced HDL cholesterol concentration and altered metabolism of high-density lipoprotein (Lp)A-I and LpA-I:A-II particles. In the metabolic syndrome, fenofibrate and atorvastatin may have differential effects on HDL particle kinetics. RESEARCH DESIGN AND

methodsEleven men with metabolic syndrome were studied in a randomized, double-blind, crossover trial of 5-week intervention periods with placebo, fenofibrate (200 mg/day), and atorvastatin (40 mg/day). LpA-I and LpA-I:A-II kinetics were examined using stable isotopic techniques and compartmental modeling.

resultsCompared with placebo, fenofibrate significantly increased the production of both LpA-I:A-II (30% increase; P < 0.001) and apoA-II (43% increase; P < 0.001), accounting for significant increases of their corresponding plasma concentrations (10 and 23% increases, respectively), but it did not alter LpA-I kinetics or concentration. Atorvastatin did not significantly alter HDL concentration or the kinetics of HDL particles.

conclusionsIn the metabolic syndrome, fenofibrate, but not atorvastatin, influences HDL metabolism by increasing the transport of LpA-I:A-II particles.

Indexed as

AtorvastatinCross-Over StudiesDouble-Blind MethodFenofibrateHeptanoic AcidsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypolipidemic AgentsKineticsLipoprotein(a)Lipoproteins, HDLMaleMetabolic SyndromeNephelometry and TurbidimetryPlacebosPyrrolesAtorvastatinFenofibrateHeptanoic AcidsHydroxymethylglutaryl-CoA Reductase InhibitorsHypolipidemic AgentsLipoprotein(a)lipoprotein A-Ilipoprotein A-IILipoproteins, HDLPlacebosPyrroles

Identifiers

PMID19651918
PMCPMC2768190
OpenAlexW2104086616

What Socratic holds

Texttitle and abstract
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.