ArticleAmerican journal of physiology. Heart and circulatory physiology2009
Left ventricular remodeling with exercise in hypertension.
Article in American journal of physiology. Heart and circulatory physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- The Roles of Aerobic Exercise and Folate Supplementation in Hyperhomocysteinemia-Accelerated Atherosclerosis.Acta Cardiologica Sinica · 2023Article
- Anti-apoptotic and anti-fibrotic efficacy of exercise training in hypertensive hearts: A systematic review.Frontiers in cardiovascular medicine · 2023Review
- Physical Exercise and Regulation of Intracellular Calcium in Cardiomyocytes of Hypertensive Rats.Arquivos brasileiros de cardiologia · 2018Article
- Metabolic Mechanisms of Exercise-Induced Cardiac Remodeling.Frontiers in cardiovascular medicine · 2018Review
- An "Exercise" in Cardiac Metabolism.Frontiers in cardiovascular medicine · 2018Review
- Acute aerobic exercise increases exogenously infused bone marrow cell retention in the heart.Physiological reports · 2015Article
- Influence of Physical Activity on Hypertension and Cardiac Structure and Function.Current hypertension reports · 2015Review
- Moderate-intensity treadmill exercise training decreases murine cardiomyocyte cross-sectional area.Physiological reports · 2015Article
- Exercise performed around MLSS decreases systolic blood pressure and increases aerobic fitness in hypertensive rats.BMC physiology · 2015Article
- Concomitant low-dose doxorubicin treatment and exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Quercetin effects on weight gain and caloric intake in exercised rats.Biology of sport · 2014Article
- Effects of hypertension and exercise on cardiac proteome remodelling.BioMed research international · 2014Review
- Is exercise really deleterious for the hypertensive heart?The Journal of physiology · 2013Article
- Heart failure with preserved ejection fraction: chronic low-intensity interval exercise training preserves myocardial O2 balance and diastolic function.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Assessment of maximal lactate steady state during treadmill exercise in SHR.BMC research notes · 2012Article
- Cardiac remodeling and function following exercise and angiotensin II receptor antagonism.European journal of applied physiology · 2012Article
- Acute exercise exacerbates ischemia-induced diastolic rigor in hypertensive myocardium.SpringerPlus · 2012Article
- Exercise training improves systolic function in hypertensive myocardium.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- Size, shape, and stamina: the impact of left ventricular geometry on exercise capacity.Hypertension (Dallas, Tex. : 1979) · 2010Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
We investigated how exercise training superimposed on chronic hypertension impacted left ventricular remodeling. Cardiomyocyte hypertrophy, apoptosis, and proliferation in hearts from female spontaneously hypertensive rats (SHRs) were examined. Four-month-old SHR animals were placed into a sedentary group (SHR-SED; n = 18) or a treadmill running group (SHR-TRD, 20 m/min, 1 h/day, 5 days/wk, 12 wk; n = 18). Age-matched, sedentary Wistar Kyoto (WKY) rats were controls (n = 18). Heart weight was greater in SHR-TRD vs. both WKY (P < 0.01) and SHR-SED (P < 0.05). Morphometric-derived left ventricular anterior, posterior, and septal wall thickness were increased in SHR-SED relative to WKY and augmented in SHR-TRD. Cardiomyocyte surface area, length, and width were increased in SHR-SED relative to WKY and further increased in SHR-TRD. Calcineurin abundance was increased in SHR-SED vs. WKY (P < 0.001) and attenuated in SHR-TRD relative to SHR-SED (P < 0.05). Protein abundance and mRNA of Akt was not different among groups. The rate of apoptosis was increased in SHR-SED relative to WKY and mitigated in SHR-TRD. The abundance of Ki-67(+) cells across groups was not statistically different across groups. The abundance of cardiac progenitor cells (c-Kit(+) cells) was increased in SHR-TRD relative to WKY. These data suggest that exercise training superimposed on hypertension augmented cardiomyocyte hypertrophy, despite attenuating calcineurin abundance. Exercise training also mitigated apoptosis in hypertension and showed a tendency to enhance the abundance of cardiac progenitor cells, resulting in a more favorable cardiomyocyte number in the exercise-trained hypertensive heart.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.