ArticleJournal of vascular research2010
Protein expression in vascular endothelial cells obtained from human peripheral arteries and veins.
Article in Journal of vascular research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes
Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System
Who cites it
33 citing papers in PubMed, 43 citations in OpenAlex.
- Vascular Function and Uric Acid-Lowering in Stage 3 CKD.Journal of the American Society of Nephrology : JASN · 2017Trial
- Acute effect of mineralocorticoid receptor antagonism on vascular function in healthy older adults.Experimental gerontology · 2016Trial
- A novel minimally-invasive method to sample human endothelial cells for molecular profiling.PloS one · 2015Trial
- Mineralocorticoid receptors modulate vascular endothelial function in human obesity.Clinical science (London, England : 1979) · 2013Trial
- Article
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- Impaired microvascular insulin-dependent dilation in women with a history of gestational diabetes.American journal of physiology. Heart and circulatory physiology · 2024Article
- Circulating extracellular microvesicles associated with electronic cigarette use increase endothelial cell inflammation and reduce nitric oxide production.Experimental physiology · 2024Article
- Antecubital venous endothelial ETB receptor protein expression is preserved with aging in men.American journal of physiology. Heart and circulatory physiology · 2024Article
- Effects of circulating endothelial microvesicles isolated from adults with obesity on endothelial cell inflammation, apoptosis, and nitric oxide production.American journal of physiology. Endocrinology and metabolism · 2024Article
- Inspiratory muscle strength training for lowering blood pressure and improving endothelial function in postmenopausal women: comparison with "standard of care" aerobic exercise.Frontiers in physiology · 2022Article
- Vascular Endothelial Function in Midlife/Older Adults Classified According to 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines.Journal of the American Heart Association · 2020Article
- Altered endothelial ETAmerican journal of physiology. Heart and circulatory physiology · 2020Article
- Endothelin-1-induced endothelial microvesicles impair endothelial cell function.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Alterations in Vascular Function Associated With the Use of Combustible and Electronic Cigarettes.Journal of the American Heart Association · 2020Article
- Impact of Red Beetroot Juice on Vascular Endothelial Function and Cardiometabolic Responses to a High-Fat Meal in Middle-Aged/Older Adults with Overweight and Obesity: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.Current developments in nutrition · 2019Article
- Comparative Transcriptomics ofJACC. Basic to translational science · 2019Article
- Circulating Microparticles Are Elevated in Treated HIV -1 Infection and Are Deleterious to Endothelial Cell Function.Journal of the American Heart Association · 2019Article
- Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function.American journal of physiology. Heart and circulatory physiology · 2017Article
- Restoration of autophagy in endothelial cells from patients with diabetes mellitus improves nitric oxide signaling.Atherosclerosis · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Studying molecular mechanisms of vascular endothelial function in humans is difficult in part because of limited access to arteries. Access to peripheral veins is more practical. We determined if differences in protein expression of endothelial cells (EC) collected from a peripheral artery are reflected in measurements made on EC obtained from peripheral veins. EC were collected from the brachial artery and an antecubital vein of 106 healthy adults (60 men and 46 women, age 18-77 years). Quantitative immunofluorescence was used to measure protein expression of endothelial nitric oxide synthase (eNOS), Ser-1177 phosphorylated eNOS, manganese superoxide dismutase, nitrotyrosine, xanthine oxidase and nuclear factor-kappaB p65. Protein expression in EC obtained from brachial artery and antecubital vein sampling was moderately to strongly related (r = 0.59-0.81, all p < 0.0001, mean r = 0.70). Moreover, differences between subgroups in the lowest and highest tertiles of protein expression in EC obtained from arterial samples were consistently reflected in EC obtained from venous collections. These findings indicate that interindividual and group differences in expression of several proteins involved in nitric oxide production, oxidant production, antioxidant defense and inflammatory signaling in EC obtained from brachial artery sampling are consistently reflected in EC obtained from venous samples. Thus, EC collected from peripheral veins may provide a useful surrogate for EC obtained from arteries for measurements of EC protein expression in humans.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.