ArticleBMC genetics2009
Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites.
Article in BMC genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01231958 (The Boston Puerto Rican Health Study), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Boston Puerto Rican Health Study: Center for Population Health and Health Disparities
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
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- High genetic burden of type 2 diabetes can promote the high prevalence of disease: a longitudinal cohort study in Iran.Scientific reports · 2020Article
- The Association Between Schizophrenia Risk Variants and Creativity in Healthy Han Chinese Subjects.Frontiers in psychology · 2019Article
- Whole-exome sequencing in maya indigenous families: variant in PPP1R3A is associated with type 2 diabetes.Molecular genetics and genomics : MGG · 2018Article
- Health conditions and lifestyle risk factors of adults living in Puerto Rico: a cross-sectional study.BMC public health · 2018Article
- Insights into the genetics of blood pressure in black South African individuals: the Birth to Twenty cohort.BMC medical genomics · 2018Article
- Type 2 diabetes mellitus: distribution of genetic markers in Kazakh population.Clinical interventions in aging · 2018Article
- Population differentiation in allele frequencies of obesity-associated SNPs.BMC genomics · 2017Article
- Article
- Association of ATP-binding cassette transporter A1 gene polymorphisms with plasma lipid variability and coronary heart disease risk.International journal of clinical and experimental pathology · 2015Article
- Distribution of cytokine gene single nucleotide polymorphisms among a multi-ethnic Iranian population.Advanced biomedical research · 2015Article
- The longitudinal association of vitamin D serum concentrations & adiposity phenotype.The Journal of steroid biochemistry and molecular biology · 2014Review
- Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations.Genome medicine · 2014Article
- CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits.BioData mining · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundVariations in gene allele frequencies can contribute to differences in the prevalence of some common complex diseases among populations. Natural selection modulates the balance in allele frequencies across populations. Population differentiation (FST) can evidence environmental selection pressures. Such genetic information is limited in Puerto Ricans, the second largest Hispanic ethnic group in the US, and a group with high prevalence of chronic disease. We determined allele frequencies and population differentiation for 101 single nucleotide polymorphisms (SNPs) in 30 genes involved in major metabolic and disease-relevant pathways in Puerto Ricans (n = 969, ages 45-75 years) and compared them to similarly aged non-Hispanic whites (NHW) (n = 597).
resultsMinor allele frequency (MAF) distributions for 45.5% of the SNPs assessed in Puerto Ricans were significantly different from those of NHW. Puerto Ricans carried risk alleles in higher frequency and protective alleles in lower frequency than NHW. Patterns of population differentiation showed that Puerto Ricans had SNPs with exceptional FST values in intronic, non-synonymous and promoter regions. NHW had exceptional FST values in intronic and promoter region SNPs only.
conclusionThese observations may serve to explain and broaden studies on the impact of gene polymorphisms on chronic diseases affecting Puerto Ricans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.