ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2009
Safety assessment of black cumin fixed and essential oil in normal Sprague Dawley rats: Serological and hematological indices.
Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05343767 (A Phase II, Randomized, Double Blind, Double Dummy, Active-Controlled Clinical Trial to Investigate the Efficacy and Safety of Low-Glu in Patients Newly Diagnosed With Type II Diabetes Mellitus), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase II, Randomized, Double Blind, Double Dummy, Active-Controlled Clinical Trial to Investigate the Efficacy and Safety of Low-Glu in Patients Newly Diagnosed With Type II Diabetes Mellitus
Who cites it
9 citing papers in PubMed, 45 citations in OpenAlex.
- Trial
- Cardiac Inotropic Effect of Long-Term Administration of Oral Thymoquinone.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Natural therapeutic approach ofIntegrative medicine research · 2018Review
- North African Medicinal Plants Traditionally Used in Cancer Therapy.Frontiers in pharmacology · 2017Review
- Antihyperglycemic effect of thymoquinone and oleuropein, on streptozotocin-induced diabetes mellitus in experimental animals.Pharmacognosy magazine · 2015Article
- Nigella sativa fixed and essential oil modulates glutathione redox enzymes in potassium bromate induced oxidative stress.BMC complementary and alternative medicine · 2015Article
- Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus.BMC complementary and alternative medicine · 2014Article
- Nigella sativa Fixed and Essential Oil Supplementation Modulates Hyperglycemia and Allied Complications in Streptozotocin-Induced Diabetes Mellitus.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Study on the potential toxicity of a thymoquinone-rich fraction nanoemulsion in Sprague Dawley rats.Molecules (Basel, Switzerland) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Black cumin (Nigella sativa L.) is unique in its nutritional profile and it's fixed and essential oils are phytochemicals rich fractions. However, safety assessment is required before recommending their use. This study was designed to evaluate the safety of black cumin fixed oil (BCFO) and black cumin essential oil (BCEO) through animal modeling using Sprague dawley rats as test animals. The results indicated that BCFO @ 4.0% and BCEO @ 0.30% are safe as serological indices like liver and kidney functioning tests, serum protein profile, level of cardiac enzymes, electrolytes balance were remained in the normal ranges even after 56days of study. Similarly, indices of red and white blood cells remained within the defined limits. Moreover, diets were insignificant in their impression regarding organs to body weight ratio. However, group of rats fed on BCFO gained less weight as compared to control that shows slight anorexic effect of BCFO which can be useful in obesity related disorders. In the nutshell, presence of phytochemicals in black cumin fixed and essential oils as well as their safe status can positively be used against lifestyle disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.