ReviewJournal of cardiovascular pharmacology2009
Mechanisms of gap junction traffic in health and disease.
Review in Journal of cardiovascular pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 56 citations in OpenAlex.
- Heme oxygenase/carbon monoxide system and cardiac conduction system.Medical gas research · 2026Review
- Article
- The Role of Connexin 36 Gap Junctions in Retinal Ganglion Cell Death After Corneal Alkali Burns.Investigative ophthalmology & visual science · 2025Article
- Article
- Review
- Looking both ways: Electroactive biomaterials with bidirectional implications for dynamic cell-material crosstalk.Biophysics reviews · 2024Review
- Glycation in the cardiomyocyte.Vitamins and hormones · 2024Review
- The effects of inflammation on connexin 43 in chronic Chagas disease cardiomyopathy.Frontiers in immunology · 2024Article
- Endothelial cell dysfunction in cardiac disease: driver or consequence?Frontiers in cell and developmental biology · 2023Review
- Contemporary management of ventricular arrhythmias in heart failure.American journal of cardiovascular disease · 2023Review
- Structure and Function of Cochlear Gap Junctions and Implications for the Translation of Cochlear Gene Therapies.Frontiers in cellular neuroscience · 2019Article
- Intracellular trafficking pathways of Cx43 gap junction channels.Biochimica et biophysica acta. Biomembranes · 2018Review
- Spatio-temporal regulation of connexin43 phosphorylation and gap junction dynamics.Biochimica et biophysica acta. Biomembranes · 2018Review
- Progesterone Via its Type-A Receptor Promotes Myometrial Gap Junction Coupling.Scientific reports · 2017Article
- The "tail" of Connexin43: An unexpected journey from alternative translation to trafficking.Biochimica et biophysica acta · 2016Review
- Connexin 43 and CaV1.2 Ion Channel Trafficking in Healthy and Diseased Myocardium.Circulation. Arrhythmia and electrophysiology · 2016Review
- MicroRNA-19b Downregulates Gap Junction Protein Alpha1 and Synergizes with MicroRNA-1 in Viral Myocarditis.International journal of molecular sciences · 2016Article
- Role of CAPE on cardiomyocyte protection via connexin 43 regulation under hypoxia.International journal of medical sciences · 2016Article
- Proteomic Analysis of Connexin 43 Reveals Novel Interactors Related to Osteoarthritis.Molecular & cellular proteomics : MCP · 2015Article
- Cardiomyocyte protein trafficking: Relevance to heart disease and opportunities for therapeutic intervention.Trends in cardiovascular medicine · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Gap junctions (GJs) allow direct communication between cells. In the heart, GJs mediate the electrical coupling of cardiomyocytes and as such dictate the speed and direction of cardiac conduction. A prominent feature of acquired structural heart disease is remodeling of GJ protein expression and localization concomitant with increased susceptibility to lethal arrhythmias, leading many to hypothesize that the two are causally linked. Detailed understanding of the cellular mechanisms that regulate GJ localization and function within cardiomyocytes may therefore uncover potential therapeutic strategies for a significant clinical problem. This review will outline our current understanding of GJ cell biology with the intent of highlighting cellular mechanisms responsible for GJ remodeling associated with cardiac disease.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.