Evidence map›Paper›PMID 19712795›Full record

ReviewJournal of the American College of Cardiology2009

Microvascular angina and the continuing dilemma of chest pain with normal coronary angiograms.

Richard O Cannon

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the American College of Cardiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02910154 nacompletedstarted 2016, after this paper: background citation

Comprehensive Treatment of Angina in Women With Microvascular Dysfunction - a Proof of Concept Study of the iPower Cohort

Ran2016Enrolled62Registered outcomes9Posted comparisons0ConditionsAngina Pectoris, Coronary Microvascular DiseaseArmsdiet, Medication (with statin and ACE-inhibition), training
PMID 19878986PMID 7829785PMID 10675425PMID 11788217PMID 11991214PMID 12147179PMID 12914662PMID 13394341PMID 15007010PMID 15020531PMID 15671433PMID 16368303other papers from this trial
Open the trial in the graph
NCT02611596 nawithdrawnnot on this mapstarted 2016, after this paper: background citation

Does Ranolazine Decrease Biomarkers That Indicate Evidence of Myocardial Damage in Diabetics With Stable Ischemic Heart Disease? A Double-blinded, Randomized, Placebo Controlled Trial

TypeinterventionalSponsorWalter Reed National Military Medical CenterRan2016 to 2019Enrolled0ConditionsSilent Myocardial Ischemia, Type 2 DiabetesArmsRanolazine, Placebo
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 136 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Validity of tortuosity severity index in chest pain patients with abnormal exercise test and normal coronary angiography.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Richard O CannonTranslational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. cannonr@nih.gov
National Heart Lung and Blood Institute · US

Funding

Worksite Wellness Interventions on Vascular Function, Insulin Sensitivity, HDLZIAHL005077 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CANNON, RICHARD · 2009 to 2014
$5.9M
Intramural NIH HHS Z99 HL999999
6 · The paper itself

Abstract

Since initial reports over 4 decades ago, cases of patients with angina-like chest pain whose coronary angiograms show no evidence of obstructive coronary artery disease and who have no structural heart disease continue to be a common occurrence for cardiologists. Many features of this patient population have remained constant with successive reports over time: a female predominance, onset of symptoms commonly between 40 and 50 years of age, pain that is severe and disabling, and inconsistent responses to conventional anti-ischemic therapy. Because patients may have had abnormal noninvasive testing that led to performance of coronary angiography, investigators have sought to show an association of this syndrome with myocardial ischemia. Abnormalities in coronary flow and metabolic responses to stress have been reported by several groups, findings consistent with a microvascular etiology for ischemia and symptoms, but others have questioned the presence of ischemia, even in patients selected for abnormal noninvasive testing. Despite considerable efforts by many groups over 4 decades, the syndrome remains controversial with regard to pathophysiology, diagnosis, and management.

Indexed as

Coronary AngiographyAdultAnimalsChest PainCoronary Artery DiseaseCoronary CirculationCoronary VesselsEndothelium, VascularFemaleHumansMicrocirculationMicrovascular AnginaMiddle AgedMyocardial IschemiaNitric Oxideomega-N-MethylarginineNitric Oxideomega-N-Methylarginine

Identifiers

PMID19712795
PMCPMC3299059
OpenAlexW2030877025

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.