ArticleGenes & development2009
Drosophila Minus is required for cell proliferation and influences Cyclin E turnover.
Article in Genes & development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Functional consequences of somatic polyploidy in development.Development (Cambridge, England) · 2024Review
- Tissue-Specific DNA Replication Defects inGenetics · 2020Article
- DNA Replication Control DuringGenetics · 2017Review
- Endoreplication.Cold Spring Harbor perspectives in biology · 2013Review
- MicroRNA transgene overexpression complements deficiency-based modifier screens in Drosophila.Genetics · 2012Article
- The kinase Sgg modulates temporal development of macrochaetes in Drosophila by phosphorylation of Scute and Pannier.Development (Cambridge, England) · 2012Article
- Cell competition and its implications for development and cancer.Journal of genetics and genomics = Yi chuan xue bao · 2011Review
- Dampened activity of E2F1-DP and Myb-MuvB transcription factors in Drosophila endocycling cells.Journal of cell science · 2010Article
- Drosophila microRNAs 263a/b confer robustness during development by protecting nascent sense organs from apoptosis.PLoS biology · 2010Article
- Endoreplication: polyploidy with purpose.Genes & development · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Turnover of cyclins plays a major role in oscillatory cyclin-dependent kinase (Cdk) activity and control of cell cycle progression. Here we present a novel cell cycle regulator, called minus, which influences Cyclin E turnover in Drosophila. minus mutants produce defects in cell proliferation, some of which are attributable to persistence of Cyclin E. Minus protein can interact physically with Cyclin E and the SCF Archipelago/Fbw7/Cdc4 ubiquitin-ligase complex. Minus does not affect dMyc, another known SCF(Ago) substrate in Drosophila. We propose that Minus contributes to cell cycle regulation in part by selectively controlling turnover of Cyclin E.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.