ArticleMagnetic resonance in medicine2009
Detection of lactate with a hadamard slice selected, selective multiple quantum coherence, chemical shift imaging sequence (HDMD-SelMQC-CSI) on a clinical MRI scanner: Application to tumors and muscle ischemia.
Article in Magnetic resonance in medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- MRS and Optical Imaging Studies of Therapeutic Response to Combination Therapy Targeting BRAF/MEK in Murine Melanomas.Academic radiology · 2026Article
- Fast acquisition of high resolution liquid NMR spectroscopy.Magnetic resonance letters · 2026Review
- The Role of Tumor pH in Breast Cancer Imaging: Biology, Diagnostic Applications, and Emerging Techniques.Diagnostics (Basel, Switzerland) · 2025Review
- In-phase simultaneous spectral editing of lactate and alanine with suppression of J-coupled lipids by the modified selective multiple quantum coherence sequences.Magnetic resonance imaging · 2022Article
- Coherence pathway analysis of J-coupled lipids and lactate and effective suppression of lipids upon the selective multiple quantum coherence lactate editing sequence.Biomedical physics & engineering express · 2022Article
- Metabolic Detection of Bruton's Tyrosine Kinase Inhibition in Mantle Cell Lymphoma Cells.Molecular cancer research : MCR · 2019Article
- Imaging Cancer Metabolism: Underlying Biology and Emerging Strategies.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018Review
- Single-shot single-voxel lactate measurements using FOCI-LASER and a multiple-quantum filter.NMR in biomedicine · 2015Article
- Evaluation of lactate detection using selective multiple quantum coherence in phantoms and brain tumours.NMR in biomedicine · 2015Article
- MR-detectable metabolic consequences of mitogen-activated protein kinase kinase (MEK) inhibition.NMR in biomedicine · 2014Article
- Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
- Treatment with the MEK inhibitor U0126 induces decreased hyperpolarized pyruvate to lactate conversion in breast, but not prostate, cancer cells.NMR in biomedicine · 2013Article
- Decreased lactate concentration and glycolytic enzyme expression reflect inhibition of mTOR signal transduction pathway in B-cell lymphoma.NMR in biomedicine · 2013Article
- Lactate detection in inducible and orthotopic Her2/neu mammary gland tumours in mouse models.NMR in biomedicine · 2013Article
- The fast spiral-SelMQC technique for in vivo MR spectroscopic imaging of polyunsaturated fatty acids in human breast tissue.Magnetic resonance in medicine · 2012Article
- Article
- MR-visible lipids and the tumor microenvironment.NMR in biomedicine · 2011Review
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Lactate is an important metabolite in normal and malignant tissues detectable by NMR spectroscopy; however, it has been difficult to clinically detect the lactate methyl resonance because it is obscured by lipid resonances. The selective homonuclear multiple quantum coherence transfer technique offers a method for distinguishing lipid and lactate resonances. We implemented a three-dimensional selective homonuclear multiple quantum coherence transfer version with Hadamard slice selection and two-dimensional phase encoding (Hadamard encoded-selective homonuclear multiple quantum coherence transfer-chemical shift imaging) on a conventional clinical MR scanner. Hadamard slice selection is explained and demonstrated in vivo. This is followed by 1-cm(3) resolution lactate imaging with detection to 5-mM concentration in 20 min on a 3-T clinical scanner. An analysis of QSel gradient duration and amplitude effects on lactate and lipid signal is presented. To demonstrate clinical feasibility, a 5-min lactate scan of a patient with a non-Hodgkin's lymphoma in the superficial thigh is reported. The elevated lactate signal coincides with the T(2)-weighted image of this tumor. As a test of selective homonuclear multiple quantum coherence transfer sensitivity, a thigh tourniquet was applied to a normal volunteer and an increase in lactate was detected immediately after tourniquet flow constriction. In conclusion, the Hadamard encoded-selective homonuclear multiple quantum coherence transfer-chemical shift imaging sequence is demonstrated on a phantom and in two lipid-rich, clinically relevant, in vivo conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.